INT83190

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 12.47
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Olr1) extracellular region (Olr1) cell adhesion (Olr1)
plasma membrane (Olr1) cellular_component (Olr1)
Anatomy Link Frequency
plasma 7
plaque 2
heart 2
blood 1
monocytes 1
Olr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 1 99.56 Very High Very High Very High
Angina 59 99.20 Very High Very High Very High
antagonist 13 92.32 High High
chest pain 1 88.12 High High
metalloproteinase 2 87.08 High High
Percutaneous transluminal coronary angioplasty 6 85.12 High High
Inflammation 2 80.84 Quite High
intrathecal 2 58.08 Quite High
cytokine 3 50.00 Quite Low
agonist 1 42.72 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 6 100.00 Very High Very High Very High
Cardiovascular Disease 20 99.96 Very High Very High Very High
Atherosclerosis 12 99.84 Very High Very High Very High
Angina 19 99.20 Very High Very High Very High
Coronary Artery Disease 48 99.12 Very High Very High Very High
Hyperlipidemia 1 98.72 Very High Very High Very High
Restenosis 6 98.60 Very High Very High Very High
Hypertension 8 98.32 Very High Very High Very High
Acute Coronary Syndrome 37 98.28 Very High Very High Very High
Injury 3 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of plasma levels of oxidized low density lipoprotein (OxLDL) in the development of coronary heart disease (CHD) has not been fully elucidated.
Gene_expression (levels) of OxLDL in heart associated with coronary artery disease
1) Confidence 0.59 Published 2008 Journal International heart journal Section Abstract Doc Link 18971563 Disease Relevance 0.84 Pain Relevance 0.13
Elevated plasma levels of OxLDL were associated with CHD, especially with ACS.
Gene_expression (levels) of OxLDL in plasma associated with acute coronary syndrome and coronary artery disease
2) Confidence 0.59 Published 2008 Journal International heart journal Section Abstract Doc Link 18971563 Disease Relevance 1.45 Pain Relevance 0.17
Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL.
Gene_expression (present) of oxLDL in plaques associated with atherosclerotic plaque and atherosclerosis
3) Confidence 0.55 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16298691 Disease Relevance 0.79 Pain Relevance 0.20
Oxidation of LDL induces production of autoantibodies against oxLDL (oxLDLab) that can be measured using an EIA test.
Gene_expression (production) of oxLDL
4) Confidence 0.55 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16298691 Disease Relevance 0.96 Pain Relevance 0.29
Plasma levels of OxLDL were significantly higher in patients with new-onset type ACS than in those with worsening type ACS (2.98 versus 1.53 mg/dL, P = 0.002).
Gene_expression (levels) of OxLDL in Plasma associated with acute coronary syndrome
5) Confidence 0.53 Published 2008 Journal International heart journal Section Abstract Doc Link 18971563 Disease Relevance 1.44 Pain Relevance 0.17
METHODS AND RESULTS: Circulating ox-LDL were assessed, using ELISA, in patients with unstable angina (UA, n=26), stable angina (SA, n=29) and in controls (C, n=27).
Gene_expression (assessed) of ox-LDL
6) Confidence 0.53 Published 2006 Journal Atherosclerosis Section Body Doc Link 15998517 Disease Relevance 0.19 Pain Relevance 0
The role of plasma levels of oxidized low density lipoprotein (OxLDL) in the development of coronary heart disease (CHD) has not been fully elucidated.
Gene_expression (levels) of oxidized low density lipoprotein in heart associated with coronary artery disease
7) Confidence 0.52 Published 2008 Journal International heart journal Section Abstract Doc Link 18971563 Disease Relevance 0.84 Pain Relevance 0.13
Increased levels of oxLDL autoantibodies are associated with severe chest pain attacks in nondiabetic patients with CHD.
Gene_expression (levels) of oxLDL in chest associated with angina and coronary artery disease
8) Confidence 0.43 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16298691 Disease Relevance 1.28 Pain Relevance 0.52
Role of OX-1/Hcrt-1 receptors in operant self-administration of ethanol and sucrose
Gene_expression (/) of OX-1
9) Confidence 0.41 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.09
Glucose-sensitive neurons in the lateral hypothalamic area produce orexin-A (OxA) as well as orexin-B (OxB) and send their axons to the spinal dorsal horn, which predominantly expresses orexin receptor-1 (OX-1), showing a higher sensitivity to OxA.
Gene_expression (expresses) of OX-1 in lateral hypothalamic area associated with spinal dorsal horn
10) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18477704 Disease Relevance 0.08 Pain Relevance 0.13
CONCLUSION: In each Braunwald class of UAP, elevated plasma levels of ox-LDL closely relate to the presence of angiographically detected complex and thrombotic lesion morphology.


Gene_expression (levels) of ox-LDL in plasma
11) Confidence 0.25 Published 2007 Journal Circ. J. Section Body Doc Link 17456991 Disease Relevance 0.13 Pain Relevance 0
Autoantibody level against oxLDL, expressed in optical density units, was significantly higher in subjects with angina pectoris compared to controls (0.100+/-0.064 versus 0.088+/-0.051, respectively, P=0.030), but serum levels of MMP-9 did not differ significantly between these groups (54.2+/-29.9 versus 50.6+/-23.1 microg/l).
Gene_expression (expressed) of oxLDL associated with angina
12) Confidence 0.25 Published 2002 Journal Atherosclerosis Section Abstract Doc Link 11755934 Disease Relevance 0.60 Pain Relevance 0.31
Plasma ox-LDL levels in patients with Braunwald class III were significantly higher than in patients with class I (p<0.0001) or in control subjects (p<0.0001).
Gene_expression (levels) of ox-LDL in Plasma
13) Confidence 0.24 Published 2007 Journal Circ. J. Section Body Doc Link 17456991 Disease Relevance 0.17 Pain Relevance 0
This case illustrates the benefits of using plasma levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) to distinguish between myocardial injuries caused by coronary vasospasm or coronary plaque rupture.
Gene_expression (levels) of soluble lectin-like oxidized low-density lipoprotein receptor-1 in plaque associated with rupture, injury and coronary vasospasm
14) Confidence 0.18 Published 2009 Journal J Nihon Med Sch Section Abstract Doc Link 19915312 Disease Relevance 0.81 Pain Relevance 0.09
Levels of blood lipids, OX-LDL, CRP, FIB at the time of entry, 1st and 2nd month of the therapeutic course were observed and end-point events in the two groups was compared.
Gene_expression (Levels) of OX-LDL in blood
15) Confidence 0.12 Published 2003 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 14626188 Disease Relevance 0.18 Pain Relevance 0
Presence of anti-oxLDL antibodies was associated with hyperlipidemia (r = 0.25; P < 0.05) but not with other risk factors for atherosclerosis.
Gene_expression (Presence) of oxLDL associated with increased venous pressure under development and hyperlipidemia
16) Confidence 0.10 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10424430 Disease Relevance 0.92 Pain Relevance 0.32
The plasma levels of apoB, apo CIII, Ox-LDL, CETP, hs-CRP and homocysteine were equally increased in both the VSA and CAD groups.
Gene_expression (levels) of Ox-LDL in plasma
17) Confidence 0.09 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.23 Pain Relevance 0
Ang II has also been implicated in upregulating the expression of the LOX-1 receptor, which is specific for oxidized LDL cholesterol.
Gene_expression (expression) of LOX-1 receptor
18) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.07 Pain Relevance 0
CD14 and TLR-4 expression on monocytes and circulating IL-6, IL-1 beta, and oxLDL were higher in UA than in SA and C subjects (P<0.001).
Gene_expression (expression) of oxLDL in monocytes
19) Confidence 0.04 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 17600225 Disease Relevance 0.09 Pain Relevance 0
BACKGROUND: The aim of this study was to evaluate the independent effect of serum remnant-like lipoprotein particle level and insulin resistance on in-stent restenosis in nondiabetic patients with stable angina.
Gene_expression (resistance) of remnant-like lipoprotein associated with angina, cardiovascular disease and insulin resistance
20) Confidence 0.03 Published 2007 Journal Coron. Artery Dis. Section Abstract Doc Link 17496497 Disease Relevance 0.52 Pain Relevance 0.17

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