INT83201

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 93
Total Number 98
Disease Relevance 47.16
Pain Relevance 12.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 15
neuronal 4
platelets 3
neutrophils 3
endothelium 3
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 130 99.74 Very High Very High Very High
ischemia 61 99.74 Very High Very High Very High
narcan 3 99.72 Very High Very High Very High
calcitonin gene related peptide 3 99.64 Very High Very High Very High
Inflammation 430 99.16 Very High Very High Very High
aspirin 56 98.78 Very High Very High Very High
cINOD 108 98.74 Very High Very High Very High
endometriosis 85 98.72 Very High Very High Very High
antagonist 57 98.70 Very High Very High Very High
Opioid 4 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 247 100.00 Very High Very High Very High
Hypertension 452 99.92 Very High Very High Very High
Chronic Renal Failure 149 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 623 99.86 Very High Very High Very High
Pre-eclampsia 216 99.84 Very High Very High Very High
Targeted Disruption 53 99.84 Very High Very High Very High
Diabetes Mellitus 1152 99.74 Very High Very High Very High
Cv Unclassified Under Development 124 99.74 Very High Very High Very High
Cv General 4 Under Development 119 99.74 Very High Very High Very High
Hyperglycemia 179 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.
Gene_expression (expressed) of NOS-3 in platelets associated with aspirin
1) Confidence 0.78 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.09 Pain Relevance 0.23
Regulation of eNOS expression in HCAEC cell line treated with opioids and proinflammatory cytokines.
Gene_expression (expression) of eNOS associated with narcan, opioid and cytokine
2) Confidence 0.77 Published 2006 Journal Kardiol Pol Section Title Doc Link 16502366 Disease Relevance 0 Pain Relevance 0.20
The suppressive mechanisms occur not only by pretranslational inhibition of eNOS expression but also by a posttranslational decrease in endothelial NO synthase activity due to a reduction in intracellular calcium levels.


Gene_expression (expression) of eNOS
3) Confidence 0.68 Published 2005 Journal Crit. Care Med. Section Body Doc Link 15891334 Disease Relevance 0 Pain Relevance 0
HeLa cells transfected with NOS-3 exhibited an increase in NO biosynthesis following aspirin exposure, and this was associated with acetylation of the enzyme on both serine-765 and serine-771.
Gene_expression (transfected) of NOS-3 in HeLa
4) Confidence 0.68 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
However, the exact explanation for the unfavorable outcome of SAH in patients presenting the eNOS -786C allele is out of the scope of the present study.
Gene_expression (presenting) of eNOS associated with cva
5) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 1.68 Pain Relevance 0.44
According to the stepwise multiple logistic regression analysis performed in the present study, the presence of the eNOS T-786C SNP T/C genotype should be considered as significant risk factors of outcome in cases of SAH.
Gene_expression (presence) of eNOS associated with cva
6) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 1.56 Pain Relevance 0.47
Experimental studies support an important role for eNOS in the regulation of angiogenesis [4]: mice lacking eNOS gene have severely reduced angiogenesis in response to tissue ischemia [5,6] while eNOS overexpression enhances angiogenesis [7-9].
Gene_expression (overexpression) of eNOS associated with ischemia
7) Confidence 0.67 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.56 Pain Relevance 0.15
Endothelial nitric oxide synthase (eNOS) gene expression was increased by 67% ± 19% (p = 0.002) and 66% ± 16% (p = 0.039) in the CR and CREX groups, respectively (Figure 1D).
Gene_expression (expression) of eNOS
8) Confidence 0.67 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Gene_expression (expression) of endothelial NO synthase in endothelial cells associated with hypertension and cinod
9) Confidence 0.65 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.69
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Gene_expression (expression) of eNOS in endothelial cells associated with hypertension and cinod
10) Confidence 0.65 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.69
The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation.
Gene_expression (expression) of eNOS
11) Confidence 0.63 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.35 Pain Relevance 0.14
This gene polymorphism could interact with the environment to produce an even more defective eNOS enzyme with increasing endothelial cell dysfunction.
Gene_expression (produce) of eNOS in endothelial cell
12) Confidence 0.62 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.52 Pain Relevance 0
Could it be that one of the polygenic causes of T2DM involve the eNOS enzyme?
Gene_expression (enzyme) of eNOS associated with diabetes mellitus
13) Confidence 0.61 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.45 Pain Relevance 0.03
CONCLUSION: Aspirin acetylates NOS-3 acutely in platelets, and this causes an increase in its activity as well as a decrease in its phosphorylation.
Gene_expression (acetylates) of NOS-3 in platelets
14) Confidence 0.59 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
There is thus strong experimental evidence to support an important role for eNOS in the regulation of angiogenesis in animal models, however the implication of eNOS activity in collateral vessel formation in response to myocardial ischemia in humans remains unknown
Gene_expression (activity) of eNOS associated with coronary artery disease and ischemia
15) Confidence 0.58 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.58 Pain Relevance 0.17
Moreover, eNOS over expression in transgenic mice [8] or using gene transfer strategies [7,9] enhances angiogenesis in response to tissue ischemia.
Gene_expression (expression) of eNOS associated with targeted disruption and ischemia
16) Confidence 0.58 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.49 Pain Relevance 0.13
Specifically, electroacupuncture (EA) seems to prevent the reduction in NO production from endothelial NO synthetase (eNOS) and neuronal NO synthase (nNOS) that is associated with hypertension and this process involves a stomach-meridian organ but not a non-stomach-meridian organ such as the liver.
Neg (NO) Gene_expression (synthetase) of eNOS in liver associated with hypertension and electroacupuncture
17) Confidence 0.58 Published 2008 Journal J Acupunct Meridian Stud Section Abstract Doc Link 20633454 Disease Relevance 0.23 Pain Relevance 0.74
Consistently, eNOS gene expression was increased in both intervention groups, suggesting an important role of eNOS in mitochondrial biogenesis in human muscle.
Gene_expression (expression) of eNOS in muscle
18) Confidence 0.58 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.09 Pain Relevance 0
There are differences in localization and expression between eNOS and iNOS in healthy and inflamed dental pulp.
Gene_expression (expression) of eNOS in dental pulp
19) Confidence 0.57 Published 2004 Journal J. Dent. Res. Section Abstract Doc Link 15044505 Disease Relevance 0.24 Pain Relevance 0.19
In blood vessels, NO is produced by the low-input constitutive endothelial NO synthase (eNOS) and is a potent vasodilator and platelet aggregation inhibitor.
Gene_expression (produced) of eNOS in platelet
20) Confidence 0.56 Published 2000 Journal Hum. Reprod. Section Abstract Doc Link 11041226 Disease Relevance 0.19 Pain Relevance 0.09

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