INT83353

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Context Info
Confidence 0.24
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
Potency 2 100.00 Very High Very High Very High
cytokine 13 98.64 Very High Very High Very High
cINOD 1 95.12 Very High Very High Very High
Inflammation 20 84.36 Quite High
dexamethasone 5 41.92 Quite Low
rheumatoid arthritis 1 10.40 Low Low
cva 5 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 1 99.68 Very High Very High Very High
Asthma 5 95.52 Very High Very High Very High
INFLAMMATION 23 94.88 High High
Uterine Fibroids 1 60.08 Quite High
Sepsis 33 58.32 Quite High
Disease 2 57.04 Quite High
Unwanted Pregnancy 6 52.20 Quite High
Emergencies 6 50.00 Quite Low
Repression 2 36.08 Quite Low
Inflammatory Bowel Disease 1 12.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After binding to the glucocorticoid receptor (GR), they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP-1 and NF-kappa B.
Negative_regulation (repress) of glucocorticoid receptor Binding (binding) of associated with cytokine
1) Confidence 0.24 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.57 Pain Relevance 0.24
Decreased glucocorticoid receptor number/affinity
Negative_regulation (Decreased) of glucocorticoid receptor Binding (affinity) of
2) Confidence 0.13 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.41 Pain Relevance 0.23
Its binding and antagonist potency with respect to the glucocorticoid receptor is significantly reduced compared to that of mifepristone, indicating that UPA belongs to a new type of dissociated progesterone receptor modulators that have reduced antiglucorticoid activity.13,15–17 The chemical structure of progesterone, LNG and UPA is depicted in Figure 1.
Negative_regulation (reduced) of glucocorticoid receptor Binding (binding) of associated with antagonist and potency
3) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.11 Pain Relevance 0.10

General Comments

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