INT83411

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Context Info
Confidence 0.19
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.70
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
lower urinary tract 1
dendrite 1
neurons 1
IB4 1
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 6 99.68 Very High Very High Very High
Kappa opioid receptor 7 98.68 Very High Very High Very High
Neurotransmitter 2 97.16 Very High Very High Very High
Nerve growth factor 158 96.88 Very High Very High Very High
rheumatoid arthritis 3 95.04 Very High Very High Very High
Pain 16 94.80 High High
opioid receptor 3 92.20 High High
Osteoarthritis 1 91.48 High High
c fibre 1 90.24 High High
unmyelinated 1 89.88 High High
Disease Link Frequency Relevance Heat
Cystitis 10 99.40 Very High Very High Very High
Intellectual Impairment 1 98.88 Very High Very High Very High
Overactive Bladder 90 97.44 Very High Very High Very High
Rheumatoid Arthritis 3 95.04 Very High Very High Very High
Borrelia Infection 1 94.32 High High
Charcot Marie Tooth Disease 1 94.16 High High
Arthropathy 2 93.52 High High
Aggression 1 93.36 High High
Cognitive Disorder 2 92.36 High High
Urinary Dysfunction 2 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Small-diameter sensory neurons can be separated into at least two distinct populations, which include isolectin B4 (IB4)-binding and tyrosine receptor kinase (trk) A-expressing.
trk Binding (binding) of in IB4
1) Confidence 0.19 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381284 Disease Relevance 0.28 Pain Relevance 0.19
We present detailed description of a rare, mild HSAN4 phenotype associated with two novel NTRK1 mutations.
NTRK1 Binding (associated) of
2) Confidence 0.18 Published 2008 Journal Neuromuscul. Disord. Section Abstract Doc Link 18657423 Disease Relevance 0.91 Pain Relevance 0.14
Neurotrophin/Trk and/or p75NTR interactions could induce long-term changes in cells [4], including: (1) mediating neurotransmitter phenotype; (2) influencing dendrite size and synaptic reorganization; (3) increasing synaptic efficacy; and (4) controlling innervation density and target organ function.
Trk Binding (interactions) of in dendrite associated with neurotransmitter
3) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.96 Pain Relevance 0.72
Neurotrophins, through interactions with Trk and/or p75NTR receptors, may contribute to neurochemical [13,14], electrophysiological [8] and organizational [4,15] plasticity of lower urinary tract (LUT) pathways after cystitis.
Trk Binding (interactions) of in lower urinary tract associated with cystitis
4) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.94 Pain Relevance 0.82
TRK-820 bound to the nociceptin receptor with a Ki value of 380 +/- 50 nM.
TRK-820 Binding (bound) of associated with orphanin
5) Confidence 0.08 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10440101 Disease Relevance 0 Pain Relevance 0.94
At E17, almost all Na(v)1.8-expressing neurons also express the high-affinity NGF receptor TrkA, and only a small proportion bind to IB4, a marker for c-ret-expressing (glial-derived neurotrophic factor-responsive) neurons.
receptor TrkA Binding (bind) of in neurons
6) Confidence 0.07 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.76
It has been associated with mutations in the NTRK1 gene, located in 1q21-22 and encoding a high-affinity NGF receptor.
NTRK1 gene Binding (associated) of
7) Confidence 0.04 Published 2005 Journal Rev Neurol Section Abstract Doc Link 16075400 Disease Relevance 0.61 Pain Relevance 0.16

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