INT83433

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 40
Total Number 43
Disease Relevance 34.00
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plasma 4
coronary artery 1
monocyte 1
poly 1
plaques 1
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 354 100.00 Very High Very High Very High
Inflammatory response 24 99.92 Very High Very High Very High
Bioavailability 19 98.24 Very High Very High Very High
psoriasis 7 97.30 Very High Very High Very High
Angina 47 96.40 Very High Very High Very High
cytokine 63 95.44 Very High Very High Very High
beta blocker 10 94.24 High High
rheumatoid arthritis 70 92.96 High High
IPN 5 92.08 High High
headache 9 83.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 423 100.00 Very High Very High Very High
Insulin Resistance 369 100.00 Very High Very High Very High
Atherosclerosis 148 99.88 Very High Very High Very High
Obesity 809 99.84 Very High Very High Very High
Weight Loss 159 99.84 Very High Very High Very High
Cancer 50 99.84 Very High Very High Very High
Adhesions 60 99.66 Very High Very High Very High
Necrosis 18 99.60 Very High Very High Very High
Depression 96 99.56 Very High Very High Very High
Coronary Artery Disease 135 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although some studies [30,31] showed increased adiponectin level in patients with renal dysfunction but our study showed as the same of Shibata et al. [32] that there is no association between adiponectin and renal function in atherosclerotic patients with normal renal function.
Positive_regulation (increased) of adiponectin associated with atherosclerosis and renal disease
1) Confidence 0.69 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 0.63 Pain Relevance 0
Adiponectin is an independent negative predictor of coronary atherosclerotic burden
Neg (independent) Positive_regulation (independent) of Adiponectin associated with atherosclerosis
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.52 Pain Relevance 0
This study examined the possible relationship between coronary vasomotor function and the transcardiac gradient of adiponectin, reflecting adiponectin utilization and/or accumulation in the coronary vascular bed.
Spec (examined) Positive_regulation (reflecting) of adiponectin
3) Confidence 0.50 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16877558 Disease Relevance 0 Pain Relevance 0
Our data suggest that the number of mixed and non-calcified plaques decrease by 1 for each 11.5 µg/ml and 13.2 µg/ml increase in serum adiponectin levels, respectively.
Positive_regulation (increase) of adiponectin in plaques
4) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.53 Pain Relevance 0.08
Kanaya et al. [13] showed that Whites had higher median adiponectin levels than Blacks and high circulating levels of adiponectin were associated with a higher risk of CAD in older Blacks.
Positive_regulation (levels) of adiponectin associated with coronary artery disease
5) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 0.63 Pain Relevance 0
Furthermore, elevated adiponectin levels
   independently predicted adverse outcomes in 325 male patients presenting with chest pain which
   was attributed to either the underlying inflammatory state or to adiponectin resistance 7.
Positive_regulation (elevated) of adiponectin in chest associated with angina and inflammation
6) Confidence 0.45 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.17 Pain Relevance 0.20
CONCLUSIONS: Chronic pancreatitis in humans (a) is associated with the decrease in serum leptin and insulin concentrations, (b) does not affect serum adiponectin concentration but increases serum adiponectin/leptin concentration ratio, and (c) alters the interrelationship between serum adiponectin and insulin concentrations.
Neg (not) Positive_regulation (increases) of adiponectin
7) Confidence 0.45 Published 2008 Journal Pancreas Section Body Doc Link 18376301 Disease Relevance 0.05 Pain Relevance 0
This finding may stimulate the use of adiponectin in clinical and epidemiological settings because the measurement of total adiponectin is better standardized, cheaper and more accessible than the other two approaches.
Spec (may) Positive_regulation (stimulate) of adiponectin
8) Confidence 0.44 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.19 Pain Relevance 0.18
Relatively high levels of serum adiponectin in obese women, a potential indicator
    of anti-inflammatory dysfunction: Relation to sex hormone-binding globulin

It is unclear whether serum adiponectin concentrations diminish linearly with increasing

    adiposity and, if not, which factors codetermine this association. 
Positive_regulation (levels) of adiponectin associated with inflammation and obesity
9) Confidence 0.42 Published 2008 Journal International Journal of Biological Sciences Section Title Doc Link PMC2491727 Disease Relevance 0.20 Pain Relevance 0.05
This strongly indicates that patients with insulin resistance or elevated adiponectin levels may have certain subclinical features, such as chronic low-grade inflammation, that can increase the risk related to cardiac surgery.
Positive_regulation (elevated) of adiponectin associated with inflammation and insulin resistance
10) Confidence 0.42 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 1.04 Pain Relevance 0.18
In conclusion, we have shown for the first time that elevated levels of serum adiponectin are associated with coronary collateral development in patients with coronary artery disease and additionally, the present study confirms many of the metabolic associations reported previously with adiponectin.
Positive_regulation (elevated) of serum adiponectin in coronary artery associated with coronary artery disease
11) Confidence 0.41 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17409674 Disease Relevance 0.71 Pain Relevance 0.06
Moreover, patients with high HOMA levels had more solitary coronary bypass and less valve procedures performed, whereas increasing adiponectin levels were correlated with more valve procedures and less bypass procedures being performed (Table 1).


Positive_regulation (increasing) of adiponectin
12) Confidence 0.36 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.38 Pain Relevance 0.08
The observation of a significant weight loss, as well as an increase in adiponectin is consistent with earlier reports in the literature observing an association between weight loss and an increase in adiponectin levels [20].
Positive_regulation (increase) of adiponectin associated with weight loss
13) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 1.42 Pain Relevance 0
The observation of a significant weight loss, as well as an increase in adiponectin is consistent with earlier reports in the literature observing an association between weight loss and an increase in adiponectin levels [20].
Positive_regulation (increase) of adiponectin associated with weight loss
14) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 1.30 Pain Relevance 0
The current clinical study shows IGOB131 administration is associated with increases in plasma adiponectin levels and decreases in leptin and CRP levels in comparison with the placebo group.
Positive_regulation (increases) of adiponectin in plasma
15) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.92 Pain Relevance 0.08
Corrected for placebo values, the rate of increase in serum adiponectin levels in IGOB131 group followed an exponential curve (Figure 4).


Positive_regulation (increase) of adiponectin
16) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.52 Pain Relevance 0.08
In turn, adiponectin levels increased at resolution of COPD exacerbation [86].

5.4.

Positive_regulation (increased) of adiponectin associated with pulmonary disease
17) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.83 Pain Relevance 0.25
-oxidation, which was promoted by increased serum adiponectin level and activation of AMP-activated protein kinase (AMPK) [12].
Positive_regulation (increased) of adiponectin
18) Confidence 0.31 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.61 Pain Relevance 0.14
In a sample of 3289 community residents from Beijing and Shanghai, we found no evidence that depressive symptoms were associated with increased levels of various inflammatory factors (CRP and IL-6) and adipokines (adiponectin, resistin, PAI-1 and RBP4).
Positive_regulation (increased) of adiponectin associated with depression and inflammation
19) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.45 Pain Relevance 0.29
Levels of adiponectin are increased by weight reduction and by thiazoledinediones (Yu et al 2002).
Positive_regulation (increased) of adiponectin associated with weight loss
20) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.93 Pain Relevance 0.08

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