INT83592

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.27
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col6a3)
Col6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 37 96.64 Very High Very High Very High
Inflammation 23 90.12 High High
fibrosis 11 74.44 Quite High
cINOD 9 71.60 Quite High
Pain 2 68.28 Quite High
Bile 6 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 22 99.56 Very High Very High Very High
Pancreatitis 54 96.64 Very High Very High Very High
Peripheral Arterial Disease 2 96.04 Very High Very High Very High
Primary Sclerosing Cholangitis 30 92.32 High High
INFLAMMATION 25 90.84 High High
Hyperplasia 2 89.40 High High
Adenoma 6 88.76 High High
Cirrhosis 5 85.12 High High
Familial Adenomatous Polyposis 3 82.32 Quite High
Colon Cancer 3 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confocal microscopy and immunofluorescence showed that within the tumors of non-treated mice, collagen VI was present in low amounts, but was enhanced within the tumors of sulindac-treated mice.
Gene_expression (present) of collagen VI associated with cancer
1) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.80 Pain Relevance 0.13
Reverse transcription-polymerase chain reaction validated gene expression of the Col6a2 subunit of collagen VI and of Mmp7.
Gene_expression (expression) of collagen VI
2) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.80 Pain Relevance 0.14
Collagens I and V demonstrated similar patterns, but were not as prominent as collagen VI.
Neg (not) Gene_expression (prominent) of collagen VI
3) Confidence 0.61 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.76 Pain Relevance 0.17
The expression of type VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization.
Gene_expression (expression) of type VI collagen
4) Confidence 0.49 Published 1999 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 10447630 Disease Relevance 0.63 Pain Relevance 0.15
The results of the present study suggest that dysregulation of collagen VI synthesis could be an important contributing factor in the complex mechanisms of disordered matrix protein deposition leading to arthrofibrosis.
Gene_expression (synthesis) of collagen VI
5) Confidence 0.49 Published 1999 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 10447630 Disease Relevance 0.48 Pain Relevance 0.12
Collagen VI was also strongly expressed in the AIPC group (interlobular and periductal), whereas it was relatively weak in CP tissues.
Gene_expression (expressed) of Collagen VI associated with chronic pancreatitis
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.80 Pain Relevance 0.45

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