INT83611

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 31.09
Pain Relevance 11.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
muscle tissue 8
macrophages 6
endothelial cells 4
plasma 2
muscle 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 74 100.00 Very High Very High Very High
cINOD 309 99.76 Very High Very High Very High
Analgesic 29 99.76 Very High Very High Very High
Inflammation 540 99.48 Very High Very High Very High
Paracetamol 14 98.96 Very High Very High Very High
Arthritis 27 98.32 Very High Very High Very High
rheumatoid arthritis 9 98.28 Very High Very High Very High
metalloproteinase 14 98.16 Very High Very High Very High
Inflammatory marker 8 98.08 Very High Very High Very High
cytokine 81 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 356 100.00 Very High Very High Very High
Pressure And Volume Under Development 48 100.00 Very High Very High Very High
Wound Healing 9 100.00 Very High Very High Very High
Anaphylaxis 4 100.00 Very High Very High Very High
Polyps 22 99.96 Very High Very High Very High
Apoptosis 150 99.84 Very High Very High Very High
Injury 56 99.68 Very High Very High Very High
INFLAMMATION 640 99.48 Very High Very High Very High
Disease 485 99.32 Very High Very High Very High
Ulcers 180 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A nonspecific COX inhibitor, not a specific COX-2 inhibitor, reduced growth and angiogenesis of non-COX expressing cancer xenograft by inhibition of COX-1 in vascular endothelial cells.
Negative_regulation (reduced) of Gene_expression (expressing) of COX in endothelial cells associated with cancer and cox-2 inhibitor
1) Confidence 0.29 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.12
Two possible sites have been postulated for the antipyretic action of non-steroid anti-inflammatory drugs; (a) inhibition of COX in endothelial cells of hypothalamic blood vessels or (b) inhibition of COX synthesising prostaglandins near sensory receptors of sub-diaphragmatic vagal afferents.
Negative_regulation (inhibition) of Gene_expression (synthesising) of COX in blood vessels associated with inflammation and cinod
2) Confidence 0.28 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.52 Pain Relevance 1.00
We found that the expression of COX-1 and COX-2 dramatically decreased during TRAMP carcinogenesis.
Negative_regulation (decreased) of Gene_expression (expression) of COX
3) Confidence 0.26 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 17942462 Disease Relevance 0.68 Pain Relevance 0.16
AM404 also inhibits purified cyclooxygenase (COX)-1 and COX-2 and prostaglandin synthesis in lipopolysaccharide-stimulated RAW264.7 macrophages.
Negative_regulation (inhibits) of Gene_expression (synthesis) of COX in macrophages
4) Confidence 0.22 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15987694 Disease Relevance 0.25 Pain Relevance 1.02
Topical application of both extracts inhibited TPA-induced COX-2 expression.
Negative_regulation (inhibited) of Gene_expression (expression) of COX
5) Confidence 0.21 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.43 Pain Relevance 0.22
Using real-time RT-PCR, none of the salicylate derivatives tested were found to interfere with COX-2 expression.
Negative_regulation (interfere) of Gene_expression (expression) of COX
6) Confidence 0.21 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10903918 Disease Relevance 0.06 Pain Relevance 0.19
Additionally, SC-236 was revealed to inhibit the PCA response and COX-2 expression.
Negative_regulation (inhibit) of Gene_expression (expression) of COX associated with anaphylaxis
7) Confidence 0.20 Published 2007 Journal Life Sci. Section Abstract Doc Link 17822719 Disease Relevance 1.34 Pain Relevance 0.33
However, the depressed levels of G-CSF in the COX inhibitor treated groups appear not to have significantly affected BAL fluid neutrophil levels; in fact, neutrophils were slightly elevated on day 4 in the celecoxib treated group.
Negative_regulation (inhibitor) of Gene_expression (levels) of COX in neutrophils
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 0.95 Pain Relevance 0
However, this compound did not inhibit COX-2 protein expression up to a concentration of 30 microM in the BMMC, indicating that deoxypodophyllotoxin directly inhibits COX-2 activity.
Negative_regulation (inhibit) of Gene_expression (expression) of COX in BMMC
9) Confidence 0.19 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15187418 Disease Relevance 0 Pain Relevance 0.06
The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue.
Negative_regulation (loss) of Gene_expression (expression) of COX associated with cancer and cox2
10) Confidence 0.19 Published 2008 Journal Carcinogenesis Section Title Doc Link 17942462 Disease Relevance 0.61 Pain Relevance 0.18
We found that the expression of COX-1 and COX-2 dramatically decreased during TRAMP carcinogenesis.
Negative_regulation (decreased) of Gene_expression (expression) of COX
11) Confidence 0.19 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 17942462 Disease Relevance 0.68 Pain Relevance 0.16
Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor.
Neg (no) Negative_regulation (decreases) of Gene_expression (expression) of COX in endothelial cell associated with cancer and metalloproteinase
12) Confidence 0.17 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 1.42 Pain Relevance 0.31
In the present study, we show that homologous disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by approximately 80%.
Negative_regulation (reduced) of Gene_expression (disruption) of COX associated with polyps
13) Confidence 0.16 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10987272 Disease Relevance 0.26 Pain Relevance 0.06
In the present study, we show that homologous disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by approximately 80%.
Negative_regulation (reduced) of Gene_expression (disruption) of COX associated with polyps
14) Confidence 0.16 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10987272 Disease Relevance 0.26 Pain Relevance 0.06
If NSAIDs are beneficial in AD, the presumed mechanism would be inhibition of COX expressed in the brain.
Negative_regulation (inhibition) of Gene_expression (expressed) of COX in brain associated with cinod and disease
15) Confidence 0.15 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.75 Pain Relevance 0.46
The aqueous extract of corni fructus exerts anti-inflammatory and analgesic effects by suppressing COX-2 and iNOS expression through the down-regulation of NF-kappaB binding activity.
Negative_regulation (suppressing) of Gene_expression (expression) of COX associated with inflammation and analgesic
16) Confidence 0.15 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.30 Pain Relevance 0.52
This supports our hypothesis that inhibition of COX-2 expression during injury stimuli (MPTP) can reduce microglial activation, which may lead to secondary degeneration and progressive cell loss.
Negative_regulation (inhibition) of Gene_expression (expression) of COX associated with parkinson's disease and injury
17) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.87 Pain Relevance 0.08
In contrast, COX-2 gene disruption and COX-2 inhibitors moderately impaired wound healing.
Negative_regulation (impaired) of Gene_expression (disruption) of COX associated with wound healing and cox-2 inhibitor
18) Confidence 0.14 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373427 Disease Relevance 0.74 Pain Relevance 0.12
In contrast, COX-2 gene disruption and COX-2 inhibitors moderately impaired wound healing.
Negative_regulation (impaired) of Gene_expression (disruption) of COX associated with wound healing and cox-2 inhibitor
19) Confidence 0.14 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373427 Disease Relevance 0.74 Pain Relevance 0.11
The aqueous extract of corni fructus suppressed PGE(2) synthesis and NO production by inhibiting the lipopolysaccharide-induced expression of cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) in murine RAW 264.7 macrophage cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of COX in macrophage
20) Confidence 0.13 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.31 Pain Relevance 0.55

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