INT83623

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 7.35
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd59) plasma membrane (Cd59)
Anatomy Link Frequency
Schwann cells 3
nerve 1
Cd59 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 36 99.90 Very High Very High Very High
Kinase C 20 99.62 Very High Very High Very High
Demyelination 17 98.44 Very High Very High Very High
cytokine 26 98.04 Very High Very High Very High
Inflammation 52 96.84 Very High Very High Very High
Spinal cord 285 50.00 Quite Low
isoflurane 5 44.04 Quite Low
Central nervous system 145 25.96 Quite Low
ketamine 5 11.44 Low Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 36 99.90 Very High Very High Very High
Cancer 16 99.84 Very High Very High Very High
Necrosis 11 99.04 Very High Very High Very High
Demyelinating Disease 17 98.44 Very High Very High Very High
Syndrome 6 97.92 Very High Very High Very High
Lifespan 5 97.84 Very High Very High Very High
INFLAMMATION 52 96.84 Very High Very High Very High
Injury 285 47.68 Quite Low
Spinal Cord Injury 350 34.68 Quite Low
Central Nervous System Disease 140 25.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CD59 in experimental allergic neuritis.
Gene_expression (expression) of CD59 associated with experimental autoimmune neuritis and neuritis
1) Confidence 0.76 Published 1999 Journal J. Neurol. Sci. Section Title Doc Link 10450801 Disease Relevance 1.08 Pain Relevance 0.71
However, interferon gamma (IFN-gamma) or tumor necrosis factor alfa (TNF-alpha) did not upregulate the expression of CD59 on rat Schwann cells in culture.
Gene_expression (expression) of CD59 in Schwann cells associated with necrosis and cancer
2) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.06 Pain Relevance 0.69
The increased CD59 expression in EAN could therefore be due to the release of cytokines or other immunoregulatory molecules from the inflammatory cells.
Gene_expression (expression) of CD59 associated with inflammation, neuritis and cytokine
3) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.09 Pain Relevance 0.72
In EAN the expression of CD59 was increased on Schwann cells during demyelination and axonal degeneration, evaluated by immunostaining of nerve sections and teased fibres.
Gene_expression (expression) of CD59 in nerve associated with demyelination and neuritis
4) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.05 Pain Relevance 0.70
CD59, a potent complement regulatory protein that inhibits the formation of the terminal cytolytic membrane attack complex (MAC), is expressed on human and rat Schwann cells.
Gene_expression (expressed) of CD59 in Schwann cells
5) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.01 Pain Relevance 0.65
The increased expression of CD59 in EAN is likely to be important in the protection of Schwann cells from MAC.
Gene_expression (expression) of CD59 in Schwann cells associated with neuritis
6) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.04 Pain Relevance 0.67
Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.
Gene_expression (Expression) of CD59
7) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0
As discussed above for C3, mRNA expression of these complement inhibitors by PMNs was also decreased by PMA activation, suggesting that PKC activity enhancement in response to PMA stimulation inhibits PMN expression of CD59 and Crry, and therefore, may contribute to the short lifespan of several days for PMNs.
Gene_expression (expression) of CD59 associated with kinase c and lifespan
8) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.26 Pain Relevance 0.13
However, previous studies have shown that PMA and PKC activity enhanced CD59 expression in cancer cells and therefore, increased the survival of these cells [30,31].
Gene_expression (expression) of CD59 associated with kinase c and cancer
9) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.13
The contrasting PMA-induced CD59 expression in PMNs and cancer cells suggests different responses by these cell types to PMA stimulation.
Gene_expression (expression) of CD59 associated with cancer
10) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.12
Besides the early complement mRNAs, cultured PMNs also expressed mRNAs encoding for CD59 and Crry, which are inhibitors of complement-mediated lysis.
Gene_expression (expressed) of CD59
11) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.19 Pain Relevance 0.18

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