INT83624

Context Info Confidence 0.49 First Reported 1999 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.41 Pain Relevance 0.82

extracellular space (Cd59) plasma membrane (Cd59)

Anatomy Link Frequency leukocytes 1 Cd59 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuritis 6 96.48 Demyelination 3 93.00 cytokine 5 92.88 Inflammation 10 88.48 Kinase C 4 84.04 Spinal cord 57 50.00 Central nervous system 29 5.00 imagery 3 5.00 ketamine 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat Experimental Autoimmune Neuritis 6 96.48 Demyelinating Disease 3 93.00 Cancer 3 91.04 INFLAMMATION 10 88.48 Necrosis 2 83.12 Lifespan 1 80.84 Syndrome 1 80.68 Injury 57 67.92 Spinal Cord Injury 70 5.00 Central Nervous System Disease 28 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mac-1 (CD11b) positive leukocytes were localized close to the Schwann cells showing enhanced CD59 staining.

Positive_regulation (enhanced) of CD59 in leukocytes

1) Confidence 0.49 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.08 Pain Relevance 0.71

Furthermore, PMN expression of mRNAs encoding for these complement inhibitors in several other states of activity affirms the detection of membrane-bound CD59 and Crry proteins on PMN surfaces as demonstrated in previous studies [32,33], supporting a self-protective role for these PMN-generated inhibitors of complement-mediated lysis under certain stimulating conditions.

Positive_regulation (bound) of CD59

2) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.33 Pain Relevance 0.11

General Comments

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