INT83680

Context Info Confidence 0.26 First Reported 1999 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 40 Total Number 41 Disease Relevance 25.45 Pain Relevance 4.98

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)

Anatomy Link Frequency HSC 5 HSC 2 smooth muscle 1 liver 1 hepatocytes 1 FUT1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 113 99.84 Nerve growth factor 24 99.76 cINOD 14 99.58 Inflammation 392 99.24 cytokine 150 98.96 qutenza 2 98.66 Chronic pancreatitis 54 97.88 fibrosis 103 97.60 Paracetamol 9 97.52 diclofenac 1 93.92

Disease Link Frequency Relevance Heat Cirrhosis 628 100.00 Primary Sclerosing Cholangitis 200 100.00 Drug Dependence 31 100.00 Injury 468 99.64 Myeloid Leukemia 226 99.40 INFLAMMATION 441 99.30 Disease 210 98.72 Pancreatic Cancer 68 98.72 Cancer 339 98.16 Pancreatitis 54 97.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similar to VCAM1 expression, CCL2 also showed a HSC specific expression irrespective of the pathology (3.15-fold, p = 0.024, Figure 8E).

Gene_expression (expression) of HSC associated with cirrhosis

1) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.08 Pain Relevance 0.03

Densitometric analysis of samples showed a 4.71-fold (p = 0.028) higher expression in HSC compared to that of PSC (Figure 7B).

Gene_expression (expression) of HSC associated with cirrhosis and primary sclerosing cholangitis

2) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.09 Pain Relevance 0.04

Buchholz et al. compared gene expression of human HSC, PSC and skin fibroblasts [9].

Gene_expression (expression) of HSC in fibroblasts associated with cirrhosis and primary sclerosing cholangitis

3) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.88 Pain Relevance 0.21

HSC represent 5-8% of all human liver cells and reside in the space of Disse [1].

Gene_expression (represent) of HSC in HSC associated with cirrhosis

4) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.12 Pain Relevance 0.03

To selectively and specifically target HSC or PSC in chronic inflammatory diseases or in cancer, a better molecular characterization of these cells is required.

Gene_expression (target) of HSC associated with cirrhosis, inflammation, cancer, primary sclerosing cholangitis and disease

5) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 2.24 Pain Relevance 0.16

Moreover, differences in gene expression levels between HSC and PCS were more pronounced compared to disease specific stellate cells.

Gene_expression (expression) of HSC in stellate cells associated with cirrhosis and disease

6) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 2.44 Pain Relevance 0.28

An approximate F statistic approached significance (P = 0.07), indicating weak evidence in favour of a different relationship between age and both HSC and EPC for the SUD and N-SUD groups – with the SUD group having lower numbers of both HSC's and EPC's compared with NA group members of equivalent age.

Gene_expression (groups) of HSC associated with drug dependence

7) Confidence 0.18 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC1949819 Disease Relevance 0.60 Pain Relevance 0.04

The results of separate experiments with three different HSC isolations are expressed as the mean?

Gene_expression (expressed) of HSC associated with cirrhosis

8) Confidence 0.17 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.58 Pain Relevance 0.08

Of interest, exogenous HSC were mainly detected in the corticomedullary area, the part of the kidney most affected by I/R injury.

Gene_expression (detected) of HSC in kidney associated with injury

9) Confidence 0.15 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.26 Pain Relevance 0.09

Herein, the authors show that in a mouse model of HSC transplantation, SDF-1 was not required for stem cell homing due to compensatory action via the VLA-4/VCAM-1 interaction [31].

Gene_expression (transplantation) of HSC in stem cell

10) Confidence 0.15 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.26 Pain Relevance 0.04

During the last decade, the ISHAGE (International Society of Hematotherapy and Graft Engineering) method to detect CD34 HSC in haematological studies has been successfully implemented in multicenter trials [23].

Gene_expression (detect) of HSC

11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0 Pain Relevance 0

B6 mice received 0.6 × 106 CM-DiI-labelled HSC, or CM-DiI-labelled HSC pre-incubated with a CXCR4 blocking antibody (anti-CXCR4 group; 20 ?

Gene_expression (pre) of HSC

12) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.15 Pain Relevance 0.06

These results suggest that injury is necessary for HSC migration and that SDF-1 alone is not sufficient for migration.

Gene_expression (migration) of HSC associated with injury

13) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.33 Pain Relevance 0

The amount of migrated CM-DiI-labelled HSC was determined on an FACSCalibur (Becton Dickinson) and expressed as a percentage of the input.

Gene_expression (expressed) of HSC

14) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.13 Pain Relevance 0

HSC migration is not influenced by exogenous SDF-1 in vivo

Gene_expression (migration) of HSC

15) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0

Enhancing the migration of HSC to the injured kidney may result in a significant contribution of these HSC to renal repair, and hence has therapeutic potential.

Gene_expression (migration) of HSC in HSC

16) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.36 Pain Relevance 0.03

However, after neutralizing SDF-1 (Figure 3D) or CXCR4 (Figure 3E), no CM-DiI-labelled HSC could be detected in the bone marrow indicating that we have established a reliable in vivo system to disrupt the SDF-1/CXCR4-mediated migration of HSC.

Gene_expression (detected) of HSC in bone marrow

17) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.08 Pain Relevance 0

B6 mice received 0.6 × 106 CM-DiI-labelled HSC, or CM-DiI-labelled HSC pre-incubated with a CXCR4 blocking antibody (anti-CXCR4 group; 20 ?

Gene_expression (group) of HSC

18) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.16 Pain Relevance 0.06

B6 mice received 0.6 × 106 CM-DiI-labelled HSC, or CM-DiI-labelled HSC pre-incubated with a CXCR4 blocking antibody (anti-CXCR4 group; 20 ?

Gene_expression (pre) of HSC

19) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.15 Pain Relevance 0.06

Isolation of HSC

Gene_expression (Isolation) of HSC

20) Confidence 0.13 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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