INT83799

Context Info Confidence 0.82 First Reported 1999 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 10 Disease Relevance 7.86 Pain Relevance 2.23

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1) growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)

Anatomy Link Frequency band 3 liver 1 spleens 1 Bcl2l1 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 33 99.50 Clonidine 9 91.36 cerebral cortex 3 75.00 antagonist 2 40.60 fibrosis 3 30.88 cva 1 12.16 Kinase C 5 5.00 cytokine 5 5.00 Parenteral administration 2 5.00 Chronic pancreatitis 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 65 100.00 Hypoxia 33 100.00 Cancer 121 98.24 Toxicity 4 97.20 Death 23 91.68 Reprotox - General 1 39 89.48 Necrosis 5 84.00 Pancreatic Cancer 64 82.80 Injury 5 76.36 Congenital Anomalies 18 73.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the toxicity progressed, during 6 and 18 h post-AAP administration, the BCL-X(L) protein band shifted to a slower mobility band which might represent a phosphorylated form of BCL-X(L).

Phosphorylation (phosphorylated) of BCL-X in band associated with toxicity and paracetamol

1) Confidence 0.82 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 1.08 Pain Relevance 0.46

As the toxicity progressed, during 6 and 18 h post-AAP administration, the BCL-X(L) protein band shifted to a slower mobility band which might represent a phosphorylated form of BCL-X(L).

Phosphorylation (form) of BCL-X in band associated with toxicity and paracetamol

2) Confidence 0.63 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 1.02 Pain Relevance 0.46

The most dramatic changes observed in this study were: (i) substantial increase in the expression of bcl-Xl in the liver by 7-day GSPE exposure alone; (ii) significant modification bcl-Xl expression by AAP alone; and (iii) dramatic inhibition of AAP-induced modification of bcl-Xl (phosphorylation?)

Phosphorylation (phosphorylation) of bcl-Xl in liver associated with paracetamol

3) Confidence 0.53 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.50 Pain Relevance 0.67

There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.

Phosphorylation (phosphorylation) of Bcl-XL in spleens

4) Confidence 0.41 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.25 Pain Relevance 0

As expected levels of phosphorylated AKT, Bcl-2, Bcl-xL and survivin were significantly reduced in tumors from mice treated with the reg4 antibody compared to control.

Phosphorylation (phosphorylated) of Bcl-xL associated with cancer

5) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 1.00 Pain Relevance 0

JNK when activated can phosphorylate serine 62 on Bcl-xL, which effectively prevents this protein's anti-apoptotic effects [56].

Phosphorylation (phosphorylate) of Bcl-xL associated with apoptosis

6) Confidence 0.14 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.37 Pain Relevance 0

Because systemic treatment with the antibody reduces tumor growth and increases sensitivity to gemcitabine treatment, we used western blot analysis to monitor in tumors the influence of reg4 antibody treatment on the intracellular levels of proteins associated with apoptosis (phosphorylated AKT, Bcl-2, Bcl-xL and survivin) and cell cycle (cyclin D1).

Phosphorylation (phosphorylated) of Bcl-xL associated with cancer and apoptosis

7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 1.06 Pain Relevance 0

Cytosol was isolated and separated by 12% SDS-PAGE and probed with tyrosine phosphorylated (p) -Bax, Bad, Bcl-2 and Bcl-xl antibodies and bands were detected.

Phosphorylation (phosphorylated) of Bcl-xl in bands

8) Confidence 0.08 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.84 Pain Relevance 0.22

The present study aims to investigate the mechanism of phosphorylation of apoptotic proteins and tests the hypothesis that the hypoxia-induced increased tyrosine phosphorylation of apoptotic proteins Bcl-2 and Bcl-xl is Ca(2+)-influx-dependent.

Spec (investigate) Phosphorylation (phosphorylation) of Bcl-xl associated with hypoxia and apoptosis

9) Confidence 0.08 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.88 Pain Relevance 0.21

The present study aims to investigate the mechanism of phosphorylation of apoptotic proteins and tests the hypothesis that the hypoxia-induced increased tyrosine phosphorylation of apoptotic proteins Bcl-2 and Bcl-xl is Ca(2+)-influx-dependent.

Phosphorylation (phosphorylation) of Bcl-xl associated with hypoxia and apoptosis

10) Confidence 0.08 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.87 Pain Relevance 0.21

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