INT84350

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 11.60
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (REG3A) extracellular space (REG3A) extracellular region (REG3A)
cytoplasm (REG3A)
Anatomy Link Frequency
liver 4
pancreas 2
REG3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 23 97.60 Very High Very High Very High
imagery 48 82.88 Quite High
Paracetamol 2 45.28 Quite Low
Inflammation 2 25.00 Low Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 54 100.00 Very High Very High Very High
Adenocarcinoma 30 98.88 Very High Very High Very High
Pancreatic Cancer 71 98.84 Very High Very High Very High
Injury 2 98.44 Very High Very High Very High
Cancer 42 97.88 Very High Very High Very High
Aggression 6 97.64 Very High Very High Very High
Metastasis 7 97.52 Very High Very High Very High
Stress 4 96.32 Very High Very High Very High
Mucinous Cystadenoma 6 95.40 Very High Very High Very High
Malignant Neoplastic Disease 6 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that overexpression of PAP in human pancreatic ductal adenocarcinoma indicates tumor aggressiveness.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PAP associated with adenocarcinoma, cancer and aggression
1) Confidence 0.70 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.69 Pain Relevance 0.16
PAP overexpression was significantly correlated with nodal involvement, distant metastasis (P < 0.05), and short survival (P < 0.01) in pancreatic cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PAP associated with pancreatic cancer and metastasis
2) Confidence 0.70 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.49 Pain Relevance 0.18
PAP was overexpressed in 79% (30 of 38) of pancreatic ductal adenocarcinoma, 19% (7 of 36) of chronic pancreatitis, and 29% (2 of 7) of mucinous cystadenoma.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PAP associated with mucinous cystadenoma, adenocarcinoma and chronic pancreatitis
3) Confidence 0.70 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.48 Pain Relevance 0.18
Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of pancreatitis-associated protein associated with adenocarcinoma and pancreatitis
4) Confidence 0.70 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12757156 Disease Relevance 1.43 Pain Relevance 0.15
The incidence of PAP overexpression was significantly higher in pancreatic cancer than in the other pancreatic diseases (P < 0.01).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PAP associated with pancreatitis and pancreatic cancer
5) Confidence 0.70 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12757156 Disease Relevance 1.52 Pain Relevance 0.19
In contrast, overexpression of human HIP/PAP promoted liver resistance to Fas and accelerated liver regeneration with early activation/deactivation of STAT3.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PAP in liver
6) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.35 Pain Relevance 0
Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PAP associated with adenocarcinoma and pancreatitis
7) Confidence 0.50 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 12757156 Disease Relevance 1.43 Pain Relevance 0.15
In contrast, overexpression of human HIP/PAP promoted liver resistance to Fas and accelerated liver regeneration with early activation/deactivation of STAT3.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HIP in liver
8) Confidence 0.49 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.35 Pain Relevance 0
Therefore we suggest that ELISA measurements of serum HIP/HAP and MUC-1 levels could be added to a panel of tests for the routine screening of population to identify individuals at increased risk for the developing pancreatic carcinoma.
Positive_regulation (measurements) of Gene_expression (levels) of HIP associated with pancreatic cancer
9) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 1.03 Pain Relevance 0.21
Pancreatitis-associated protein (PAP) is almost absent in the normal pancreas but is overexpressed in acute pancreatitis.
Positive_regulation (overexpressed) of Neg (absent) Gene_expression (absent) of PAP in pancreas associated with pancreatitis
10) Confidence 0.11 Published 1999 Journal Pancreas Section Abstract Doc Link 10505754 Disease Relevance 0.84 Pain Relevance 0.51

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