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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.52 Very High Very High Very High
adenocard 1 84.44 Quite High
Analgesic 1 49.80 Quite Low
tolerance 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Balkan Nephropathy 6 96.84 Very High Very High Very High
Renal Disease 14 96.52 Very High Very High Very High
Obesity 3 96.08 Very High Very High Very High
Hypoglycemia 16 94.00 High High
Diabetes Mellitus 57 50.24 Quite High
Hyperinsulinism 1 33.16 Quite Low
Body Weight 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Weight Gain 6 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of metformin to obese subjects was also found to increase levels of active GLP-1 after a glucose load: this phenomenon appears to occur through mechanisms other than DPP-4 inhibition, and may instead be due to direct stimulation of GLP-1 secretion or a reduction in DPP-4 secretion (Mannucci et al 2001; Lenhard et al 2004).
Positive_regulation (stimulation) of Localization (secretion) of DPP-4 associated with obesity
1) Confidence 0.32 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.29 Pain Relevance 0.04
After acetaminophen administration urinary excretion of APN, dipeptidylpeptidase IV (DPP IV), gamma-glutamyltranspeptidase (GGT) and N-acetyl-beta-D-glucosaminidase (NAGA) did not increase significantly in any group studied.
Neg (not) Positive_regulation (increase) of Localization (excretion) of DPP IV associated with paracetamol
2) Confidence 0.05 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.98 Pain Relevance 0.81

General Comments

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