INT84546

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 7
Speculated 10
Reported most in Body
Documents 481
Total Number 494
Disease Relevance 334.21
Pain Relevance 83.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 15
macrophages 7
colon 5
plasma 3
microglia 3
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8748 100.00 Very High Very High Very High
agonist 7211 100.00 Very High Very High Very High
cINOD 1164 99.98 Very High Very High Very High
dexamethasone 199 99.98 Very High Very High Very High
Inflammatory response 771 99.92 Very High Very High Very High
Endocannabinoid 305 99.88 Very High Very High Very High
Paracetamol 162 99.88 Very High Very High Very High
COX2 701 99.86 Very High Very High Very High
analgesia 51 99.82 Very High Very High Very High
Kinase C 294 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9895 100.00 Very High Very High Very High
Cancer 9607 100.00 Very High Very High Very High
Obesity 4902 100.00 Very High Very High Very High
Diabetes Mellitus 2182 100.00 Very High Very High Very High
Shock 1442 100.00 Very High Very High Very High
Injury 1645 99.96 Very High Very High Very High
Death 1250 99.96 Very High Very High Very High
Peptic Ulcer 34 99.96 Very High Very High Very High
Disease 2650 99.92 Very High Very High Very High
Frailty 263 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 1 summarizes some of the recent literature regarding activities and effect of activation of the PPAR?
Positive_regulation (activation) of PPAR
1) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.63 Pain Relevance 0.21
Nakajima et al. (2000) reported no remarkable sex difference in TCE-induced PP in wild-type mice, as measured morphologically, but a markedly higher induction of several enzymes and PPAR?
Positive_regulation (induction) of PPAR
2) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.24 Pain Relevance 0.09
The insulin-resistant and diabetic heart is characterized by increased fatty acid oxidation rates that may be related to chronic stimulation of the PPAR?
Positive_regulation (stimulation) of PPAR in heart associated with diabetes mellitus
3) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 1.05 Pain Relevance 0
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
Positive_regulation (Activation) of PPAR associated with toxicity, paracetamol and diabetes mellitus
4) Confidence 0.69 Published 2003 Journal FASEB J. Section Title Doc Link 12958197 Disease Relevance 1.46 Pain Relevance 0.49
The role of peroxisome proliferator receptor (PPAR)-alpha activation in diabetes, in protection against lethal acetaminophen (APAP) challenge, was investigated.
Spec (investigated) Positive_regulation (activation) of PPAR associated with paracetamol and diabetes mellitus
5) Confidence 0.69 Published 2003 Journal FASEB J. Section Abstract Doc Link 12958197 Disease Relevance 1.08 Pain Relevance 0.43
-oxidation system reveal profound activation of PPAR?
Positive_regulation (activation) of PPAR
6) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.14 Pain Relevance 0
These observations strongly support that sustained activation of PPAR?
Positive_regulation (activation) of PPAR
7) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.57 Pain Relevance 0
It is evident that DNA-damaging oxidants are generated by enzymes induced after activation of PPAR?
Positive_regulation (activation) of PPAR
8) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.33 Pain Relevance 0
and transcriptional activation of PPAR?
Positive_regulation (activation) of PPAR
9) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.35 Pain Relevance 0
Accordingly, sustained activation of PPAR?
Positive_regulation (activation) of PPAR
10) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.36 Pain Relevance 0
Based on these observations, it is concluded that chronic exposure to synthetic peroxisome proliferators results in sustained activation of PPAR?
Positive_regulation (activation) of PPAR
11) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.40 Pain Relevance 0
Although many synthetic ligands activate PPAR?
Positive_regulation (activate) of PPAR
12) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.10 Pain Relevance 0
activation of PPAR?
Positive_regulation (activation) of PPAR
13) Confidence 0.69 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.82 Pain Relevance 0.07
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.
Positive_regulation (activation) of peroxisome proliferator-activated receptor-alpha associated with analgesic and analgesia
14) Confidence 0.69 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16997973 Disease Relevance 0.52 Pain Relevance 0.78
Fenofibrate not only elevated the transcriptional activation of PPAR?
Positive_regulation (activation) of PPAR
15) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.93 Pain Relevance 0
However, the expression levels were much higher in males than in females, suggesting that fenofibrate exhibits sexually dimorphic activation of PPAR?
Positive_regulation (activation) of PPAR
16) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.57 Pain Relevance 0
Thus, fenofibrate influences obesity via the differential activation of PPAR?.
Positive_regulation (activation) of PPAR associated with obesity
17) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.86 Pain Relevance 0
According to Yoon et al. [20], fenofibrate elevated the transcriptional activation of PPAR?
Positive_regulation (activation) of PPAR
18) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.57 Pain Relevance 0
Activation of PPAR?
Positive_regulation (Activation) of PPAR
19) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.79 Pain Relevance 0.50
These findings demonstrate that the protection against APAP hepatotoxicity by peroxisome proliferator treatment is mediated by the activation of PPARalpha.
Positive_regulation (activation) of PPARalpha associated with paracetamol and hepatotoxicity
20) Confidence 0.69 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 11006363 Disease Relevance 0.55 Pain Relevance 0.68

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