INT84597

Context Info Confidence 0.55 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 2.11 Pain Relevance 0.98

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency kidney 2 neural retina 1 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 6 98.72 COX-2 inhibitor 5 92.32 agonist 3 83.52 cINOD 3 80.64 ischemia 8 38.24 anesthesia 3 25.00 hyperexcitability 2 5.00 potassium channel 2 5.00

Disease Link Frequency Relevance Heat Polyuria 3 93.60 Diabetes Insipidus 7 90.96 Ganglion Cysts 18 88.64 Neurological Disease 2 75.44 Congenital Anomalies 2 71.44 Ocular Hypertension 10 66.48 Glaucoma 22 63.28 Disorders Of The Lacrimal System 2 57.20 INFLAMMATION 1 54.04 Optic Disorders 2 53.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mRNAs for AQP2, AQP10, and AQP12 were not detected in the rat neural retina [10].

Transcription (detected) of AQP2 in neural retina

1) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.76 Pain Relevance 0

The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].

Transcription (expressed) of AQP2

2) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.63 Pain Relevance 0

The increase in free water clearance with clonidine administration was associated with a reduction in whole kidney AQP-2 mRNA levels (282+/-25 versus 216+/-11 A units, p<.05).

Transcription (levels) of AQP-2 in kidney associated with clonidine

3) Confidence 0.53 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.58

Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2.

Transcription (abundance) of AQP2 in kidney

4) Confidence 0.52 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.72 Pain Relevance 0.39

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