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Context Info
Confidence 0.55
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.11
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
kidney 2
neural retina 1
Aqp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 6 98.72 Very High Very High Very High
COX-2 inhibitor 5 92.32 High High
agonist 3 83.52 Quite High
cINOD 3 80.64 Quite High
ischemia 8 38.24 Quite Low
anesthesia 3 25.00 Low Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyuria 3 93.60 High High
Diabetes Insipidus 7 90.96 High High
Ganglion Cysts 18 88.64 High High
Neurological Disease 2 75.44 Quite High
Congenital Anomalies 2 71.44 Quite High
Ocular Hypertension 10 66.48 Quite High
Glaucoma 22 63.28 Quite High
Disorders Of The Lacrimal System 2 57.20 Quite High
INFLAMMATION 1 54.04 Quite High
Optic Disorders 2 53.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNAs for AQP2, AQP10, and AQP12 were not detected in the rat neural retina [10].
Transcription (detected) of AQP2 in neural retina
1) Confidence 0.55 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.76 Pain Relevance 0
The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].
Transcription (expressed) of AQP2
2) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.63 Pain Relevance 0
The increase in free water clearance with clonidine administration was associated with a reduction in whole kidney AQP-2 mRNA levels (282+/-25 versus 216+/-11 A units, p<.05).
Transcription (levels) of AQP-2 in kidney associated with clonidine
3) Confidence 0.53 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.58
Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2.
Transcription (abundance) of AQP2 in kidney
4) Confidence 0.52 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.72 Pain Relevance 0.39

General Comments

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