INT84600

Context Info Confidence 0.17 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.35

aging (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) cytoplasm (Aqp2) response to stress (Avp) signal transducer activity (Avp)

Anatomy Link Frequency duct 1 Avp (Rattus norvegicus) Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 3 97.32 Clonidine 6 96.64 anesthesia 1 25.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aquaporin-2 (AQP-2), the major water channel responsible for water balance, has been shown to be regulated by the binding of vasopressin to V(2) vasopressin receptors in the medullary collecting duct. alpha(2)-Adrenoceptor agonists such as clonidine have been associated with an increase in free water clearance that was secondary to an inhibition of the ability of vasopressin to increase cAMP levels in the collecting ducts.

vasopressin Binding (binding) of AQP-2 in duct associated with agonist and clonidine

1) Confidence 0.17 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.35

General Comments

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