INT84605

Context Info Confidence 0.07 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.70

response to stress (Avp, Avp) signal transducer activity (Avp, Avp) extracellular space (Avp, Avp) signal transduction (Avp, Avp) extracellular region (Avp, Avp) aging (Aqp2)

Anatomy Link Frequency duct 4 Avp (Rattus norvegicus) Avp (Rattus norvegicus) Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 6 97.32 Clonidine 12 96.64 anesthesia 2 25.00

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aquaporin-2 (AQP-2), the major water channel responsible for water balance, has been shown to be regulated by the binding of vasopressin to V(2) vasopressin receptors in the medullary collecting duct. alpha(2)-Adrenoceptor agonists such as clonidine have been associated with an increase in free water clearance that was secondary to an inhibition of the ability of vasopressin to increase cAMP levels in the collecting ducts.

vasopressin Binding (binding) of vasopressin in duct Regulation (regulated) of AQP-2 associated with agonist and clonidine

1) Confidence 0.07 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.35

Aquaporin-2 (AQP-2), the major water channel responsible for water balance, has been shown to be regulated by the binding of vasopressin to V(2) vasopressin receptors in the medullary collecting duct. alpha(2)-Adrenoceptor agonists such as clonidine have been associated with an increase in free water clearance that was secondary to an inhibition of the ability of vasopressin to increase cAMP levels in the collecting ducts.

vasopressin Binding (binding) of vasopressin in duct Regulation (regulated) of Aquaporin-2 associated with agonist and clonidine

2) Confidence 0.07 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525117 Disease Relevance 0 Pain Relevance 0.35

General Comments

This test has worked.