INT84702

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.34
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
projection neurons 4
corneal epithelium 2
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
projection neuron 2 100.00 Very High Very High Very High
antinociception 12 96.36 Very High Very High Very High
intrathecal 2 85.36 High High
MU agonist 2 82.16 Quite High
Inflammation 4 81.36 Quite High
analgesia 4 77.44 Quite High
Antinociceptive 2 66.96 Quite High
Opioid 4 66.32 Quite High
tolerance 26 22.40 Low Low
addiction 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 20 92.28 High High
Diabetes Mellitus 28 83.44 Quite High
Insulin Resistance 11 81.92 Quite High
INFLAMMATION 4 81.36 Quite High
Stress 29 77.60 Quite High
Hyperglycemia 1 66.16 Quite High
Targeted Disruption 38 56.32 Quite High
Body Weight 3 54.04 Quite High
Weight Loss 3 53.04 Quite High
Prostate Cancer 54 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that the augmented spinal noradrenergic activity during HSP is not due to activation at the terminal of noradrenergic spinal projection neurons but requires supraspinal activity.
Positive_regulation (activation) of Positive_regulation (augmented) of HSP in projection neurons associated with projection neuron
1) Confidence 0.49 Published 1999 Journal Pain Section Abstract Doc Link 10534609 Disease Relevance 0 Pain Relevance 0.94
This suggests that the augmented spinal noradrenergic activity during HSP is not due to activation at the terminal of noradrenergic spinal projection neurons but requires supraspinal activity.
Neg (not) Positive_regulation (requires) of Positive_regulation (augmented) of HSP in projection neurons associated with projection neuron
2) Confidence 0.49 Published 1999 Journal Pain Section Abstract Doc Link 10534609 Disease Relevance 0 Pain Relevance 0.97
The density of the immunoreaction product in the corneal epithelium became greater, especially at the limbus, reflecting an increased accumulation of Hsp 70.
Positive_regulation (increased) of Positive_regulation (accumulation) of Hsp in corneal epithelium
3) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.49 Pain Relevance 0.12
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (increased) of Positive_regulation (activation) of HSP
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.15 Pain Relevance 0
Thus, increased AR-HSP dissociation promoted increased AR activation and AR-driven gene expression.
Positive_regulation (increased) of Positive_regulation (activation) of HSP
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.15 Pain Relevance 0
In studies applying other methods for antioxidant capacity have been used, endurance training contributed to the improved cardiac protection by enhancing the antioxidant capacity and HSP induction [54,55].
Positive_regulation (enhancing) of Positive_regulation (induction) of HSP
6) Confidence 0.02 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.56 Pain Relevance 0

General Comments

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