INT84727

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 40
Disease Relevance 12.46
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
EPI 10
22RV1 2
myocyte 2
Mouse 2
testes 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 12 100.00 Very High Very High Very High
cINOD 20 99.62 Very High Very High Very High
Potency 123 99.28 Very High Very High Very High
ischemia 8 97.64 Very High Very High Very High
addiction 14 97.56 Very High Very High Very High
antagonist 128 97.08 Very High Very High Very High
imagery 45 95.12 Very High Very High Very High
Catecholamine 35 92.56 High High
positron emission tomography 6 91.92 High High
MU agonist 2 91.52 High High
Disease Link Frequency Relevance Heat
Cancer 829 100.00 Very High Very High Very High
Reprotox - General 1 203 100.00 Very High Very High Very High
INFLAMMATION 54 99.52 Very High Very High Very High
Prostate Cancer 254 99.40 Very High Very High Very High
Death 5 99.26 Very High Very High Very High
Bladder Cancer 273 98.72 Very High Very High Very High
Cv Unclassified Under Development 14 97.64 Very High Very High Very High
Benign Prostatic Hypertrophy 32 97.40 Very High Very High Very High
Colon Cancer 7 95.76 Very High Very High Very High
Apoptosis 97 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western and northern blot analyses demonstrated that FA inhibited the androgen receptor (AR) expression at mRNA and protein levels.
Negative_regulation (inhibited) of Gene_expression (protein) of AR
1) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.38 Pain Relevance 0.41
A nonsteroidal anti-inflammatory drug, flufenamic acid, inhibits the expression of the androgen receptor in LNCaP cells.
Negative_regulation (inhibits) of Gene_expression (expression) of androgen receptor associated with inflammation and cinod
2) Confidence 0.58 Published 1999 Journal Endocrinology Section Title Doc Link 10537180 Disease Relevance 0.47 Pain Relevance 0.48
Suppressed AR expression may be the cause of FA-mediated inhibition of the androgen inducible gene expression.
Negative_regulation (Suppressed) of Gene_expression (expression) of AR
3) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.36 Pain Relevance 0.40
Western and northern blot analyses demonstrated that FA inhibited the androgen receptor (AR) expression at mRNA and protein levels.
Negative_regulation (inhibited) of Gene_expression (expression) of androgen receptor
4) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.38 Pain Relevance 0.41
In non-necrotic regions, mainly at the periphery of the tumor, a strong reduction in the level of AR expression and in the proportion of KI67-positive proliferating cells was observed (Figure 3D).
Negative_regulation (reduction) of Gene_expression (expression) of AR associated with cancer
5) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 1.36 Pain Relevance 0
In this background is the paradoxical observation that the growth of some AR-expressing "androgen sensitive" human prostate cancer cells can be inhibited by supraphysiologic levels of androgens.
Negative_regulation (inhibited) of Gene_expression (expressing) of AR associated with reprotox - general 1
6) Confidence 0.43 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.44 Pain Relevance 0.08
This raises the possibility of increasing androgen receptor expression may alter the prostate cancer cells' response to its ligand or even its antagonists.
Spec (possibility) Negative_regulation (possibility) of Gene_expression (expression) of androgen receptor associated with antagonist and prostate cancer
7) Confidence 0.41 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.58 Pain Relevance 0.12
Importantly, we observed that AR silencing reduced the VEGF synthesis in LNCaP as well as in C4-2 and 22RV1 cells (Figure 3B), demonstrating that VEGF is still regulated by AR in advanced prostate cancers.
Negative_regulation (reduced) of Gene_expression (silencing) of AR in 22RV1 associated with prostate cancer
8) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.66 Pain Relevance 0
We recently reported that AR silencing in the testes inhibits the Fibroblast Growth Factor-2 synthesis in the germ cells, a mechanism possibly involved in the induction of their apoptosis [28].
Negative_regulation (inhibits) of Gene_expression (silencing) of AR in germ cells associated with apoptosis
9) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.42 Pain Relevance 0.03
Furthermore, the AR expression in prostate and testes was not affected by treatment of mice with the siRNA selective for the human AR mRNA (Figure 2A) whereas this siRNA efficiently silenced AR in the human tumor cells and inhibited their growth in vivo (Figure 1E).
Negative_regulation (inhibited) of Gene_expression (expression) of AR in testes associated with cancer
10) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.61 Pain Relevance 0
As compared to cont-siRNA, AR expression was strongly reduced by the pan-AR-siRNA treatment in epithelial and stromal cells of the ventral prostate, and in Leydig and Sertoli cells in the testes (Figure 2A).
Negative_regulation (reduced) of Gene_expression (expression) of AR in ventral
11) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.66 Pain Relevance 0.04
As controls for the AR siRNA experiments we also measured expression of AR itself and the DHT-stimulated genes PSA [23], PRKCD, PYCR1 and MRFAP1 (Figure 2C, F, J).
Negative_regulation (measured) of Gene_expression (expression) of AR
12) Confidence 0.31 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0 Pain Relevance 0
This IL-8 induction was dependent on the AR as the inhibition of AR expression by siRNA prevented IL-8 secretion following androgen stimulation (Figure 5C).
Negative_regulation (inhibition) of Gene_expression (expression) of AR
13) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.36 Pain Relevance 0.15
We decided to further inhibit the AR by blocking the AR expression in LNCaP cells using siRNA.
Negative_regulation (blocking) of Gene_expression (expression) of AR
14) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.05 Pain Relevance 0.04
The presence of siRNA against the AR resulted in a significant inhibition of AR expression and in a reduced PSA expression following R1881 stimulation (Figure 2E).
Negative_regulation (inhibition) of Gene_expression (expression) of AR
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.12 Pain Relevance 0.04
For use in binding assays AR was expressed in the absence of radioactive S35-methionein and stored at 4°C until further used in recombinant binding assay experiments.


Negative_regulation (absence) of Gene_expression (expressed) of AR
16) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.07 Pain Relevance 0
Sample preparation for AR assays
Negative_regulation (preparation) of Gene_expression (assays) of AR
17) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.06 Pain Relevance 0
RRME treatment also decreased transcription of AR regulated genes and also reduced histone H3 and AR acetylation in the promoters of prostate-specific antigen (PSA) and beta-2-microglobulin (B2M).
Negative_regulation (reduced) of Gene_expression (acetylation) of AR
18) Confidence 0.25 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.24 Pain Relevance 0
However, following transfection of the stickleback AR?
Negative_regulation (following) of Gene_expression (transfection) of AR
19) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.08 Pain Relevance 0.03
Mouse BC explant MMUST from a male UPII-SV40T also responded to DHT treatment with an increase in cell proliferation, again despite a lack of AR protein expression (Fig. 4D).


Negative_regulation (lack) of Gene_expression (expression) of AR in Mouse associated with bladder cancer
20) Confidence 0.19 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.82 Pain Relevance 0

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