INT84825

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 121
Total Number 133
Disease Relevance 43.73
Pain Relevance 33.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocytes 28
macrophages 12
endothelial cells 2
LS174T 2
erythrocyte 1
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2259 100.00 Very High Very High Very High
cOX1 4 100.00 Very High Very High Very High
Adalimumab 7008 99.92 Very High Very High Very High
COX2 1 99.92 Very High Very High Very High
rheumatoid arthritis 2415 99.84 Very High Very High Very High
aspirin 289 99.84 Very High Very High Very High
dexamethasone 200 99.82 Very High Very High Very High
cytokine 1014 99.80 Very High Very High Very High
qutenza 3 99.30 Very High Very High Very High
chemokine 528 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2559 100.00 Very High Very High Very High
Repression 196 100.00 Very High Very High Very High
Natriuresis 1 100.00 Very High Very High Very High
Infection 128 99.98 Very High Very High Very High
Rheumatoid Arthritis 2665 99.84 Very High Very High Very High
Pulmonary Alveolar Proteinosis 16 99.84 Very High Very High Very High
Herpes Simplex Virus 238 99.78 Very High Very High Very High
Adhesions 495 99.70 Very High Very High Very High
Increased Venous Pressure Under Development 1170 99.68 Very High Very High Very High
Hypersensitivity 26 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells.
Gene_expression (expression) of CD36 in blood associated with qutenza
1) Confidence 0.78 Published 2007 Journal Immunol. Lett. Section Title Doc Link 17360047 Disease Relevance 0 Pain Relevance 0.33
Myocardial iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid uptake was absent, but thallium-201 uptake during single photon emission computed tomography was normal, and neither platelet nor monocyte expression of the CD36 molecule was observed, indicating type I CD36 deficiency.
Gene_expression (expression) of CD36 in monocyte
2) Confidence 0.78 Published 2006 Journal J Cardiol Section Abstract Doc Link 16886497 Disease Relevance 0.66 Pain Relevance 0.27
on the regulation of membrane expression of CD36, monocytes were treated with TNF?
Gene_expression (expression) of CD36 in monocytes
3) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.08
Our work shows differential regulation of CD36 expression by TNF?
Gene_expression (expression) of CD36
4) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.71 Pain Relevance 0.37
Aspirin increases CD36 expression in lines of human THP1 macrophages [23], dexamethasone induces CD36 expression in human dendritic cells from healthy subjects [24] and atorvastatin increases CD36 expression in human monocytes [36,37].
Gene_expression (expression) of CD36 in monocytes associated with aspirin and dexamethasone
5) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.16 Pain Relevance 0.25
Various products derived from lipid peroxidation induce expression of CD36 by activating regulatory transcription factors, such as nuclear factor erythroid 2-related factor 2 (Nrf2), while vitamin E represses it [20-22].
Gene_expression (expression) of CD36
6) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.64 Pain Relevance 0.31
CD36 expression was assessed by RT-PCR and flow cytometry, with various TNF?
Gene_expression (expression) of CD36
7) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906797 Disease Relevance 0.78 Pain Relevance 0.38
Different cytokines essential for the regulation of inflammatory and immune responses modulate the expression of CD36 by macrophages.
Gene_expression (expression) of CD36 in macrophages associated with inflammation and cytokine
8) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.89 Pain Relevance 0.29
(10 ng/ml) for increasing periods of time and membrane expression of CD36 was quantified using flow cytometry.
Gene_expression (expression) of CD36
9) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.08
On the other hand, the administration of antioxidants, such as vitamin E, leads to a reduction in CD36 expression in murine peritoneal macrophages, and human endothelial cells, and macrophages derived from human monocytes [20,22,39].
Gene_expression (expression) of CD36 in monocytes
10) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.07 Pain Relevance 0.24
Figure 4a shows that adalimumab increased CD36 membrane expression (233.7 ± 43.7 versus 122.8 ± 23.2, +70%, p = 0.02), while GW9662 did not significantly decrease CD36 membrane expression (93.8 ± 31.8 versus 122.8 ± 23.2, -24%, p = 0.2), in comparison to basal conditions.
Gene_expression (expression) of CD36 associated with adalimumab
11) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.39
-induced decrease of CD36 membrane expression (35.3 ± 15.5 versus 106.9 ± 11.3, p = 0.0004).
Gene_expression (expression) of CD36
12) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.09
These factors have prompted us to test the hypothesis that CD36 expression in human monocytes is regulated by TNF?
Gene_expression (expression) of CD36 in monocytes
13) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.67 Pain Relevance 0.38
The phagocytosis of oxidized low density lipoproteins (LDLs) accumulated in the subendothelium by mononuclear cells influences atherosclerosis and depends on CD36 expression.
Gene_expression (expression) of CD36 in mononuclear cells associated with increased venous pressure under development
14) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906797 Disease Relevance 0.87 Pain Relevance 0.34
Previous work reported that certain pharmacological agents, whose anti-inflammatory properties are used in human therapy, regulate in vitro CD36 expression.
Gene_expression (expression) of CD36 associated with inflammation
15) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.23 Pain Relevance 0.28
reduced membrane expression of CD36 in a dose-dependent manner: -9% (91.6 ± 10.3 versus 100.3 ± 10.9, p = 0.3), -29% (71.2 ± 13.1 versus 100.3 ± 10.9, p = 0.002) and -59% (41.4 ± 4.5 versus 100.3 ± 10.9, p = 0.003) for 0.1, 1 and 10 ng/ml TNF?
Gene_expression (expression) of CD36
16) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.13
monoclonal antibody widely used in human pathology, in CD36 expression in human monocytes.
Gene_expression (expression) of CD36 in monocytes
17) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906797 Disease Relevance 0.82 Pain Relevance 0.36
While IL4, a TH2 cytokine, induces CD36 expression via synthesis of natural PPAR?
Gene_expression (expression) of CD36 associated with cytokine
18) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.22 Pain Relevance 0.18
Some therapeutic agents used in human pathology for their anti-inflammatory properties appear to modulate expression of CD36 by monocytes/macrophages and dendritic cells: aspirin induces expression of CD36 by human macrophages while dexamethasone induces expression of CD36 by dendritic cells [23,24].
Gene_expression (expression) of CD36 in macrophages associated with aspirin, inflammation and dexamethasone
19) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.62 Pain Relevance 0.31
Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes

In chronic inflammatory diseases, such as rheumatoid arthritis, inflammation acts as an independent cardiovascular risk factor and the use of anti-inflammatory drugs, such as anti-tumor necrosis factor alpha (anti-TNF?)

Gene_expression (expression) of CD36 in monocytes associated with necrosis, inflammation, cancer, cinod, rheumatoid arthritis, adalimumab and disease
20) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906797 Disease Relevance 0.95 Pain Relevance 0.39

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