INT84881

Context Info Confidence 0.46 First Reported 1999 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 5.79 Pain Relevance 2.35

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)

Anatomy Link Frequency endothelial cell 4 platelet 4 Pecam1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 130 100.00 Percutaneous transluminal coronary angioplasty 27 100.00 analgesia 112 97.08 Opioid 254 92.88 Endogenous opioid 74 90.00 abdominal pain 3 84.08 antinociception 74 80.28 aspirin 7 79.16 cva 5 75.64 cytokine 27 75.00

Disease Link Frequency Relevance Heat INFLAMMATION 143 100.00 Adhesions 57 100.00 Shock 4 99.64 Cancer 10 99.02 Diabetes Mellitus 26 96.20 Stress 36 96.00 Ulcers 26 93.28 Hemangiosarcoma 3 93.24 Abdominal Pain 3 84.08 Weight Loss 1 82.56

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).

Positive_regulation (overexpression) of Gene_expression (overexpression) of PECAM in endothelial cell associated with diabetes mellitus, shock and adhesions

1) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.43 Pain Relevance 0.11

The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).

Positive_regulation (overexpression) of Gene_expression (overexpression) of platelet endothelial cell adhesion molecule-1 in endothelial cell associated with diabetes mellitus, shock and adhesions

2) Confidence 0.40 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.50 Pain Relevance 0.11

Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).

Positive_regulation (increased) of Gene_expression (expression) of PECAM-1 in platelet associated with inflammation and adhesions

3) Confidence 0.24 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.71 Pain Relevance 0.89

Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).

Positive_regulation (increased) of Gene_expression (expression) of platelet-endothelial adhesion molecule-1 in platelet associated with inflammation and adhesions

4) Confidence 0.21 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.72 Pain Relevance 0.94

The tumor was composed of epithelioid cells, which showed positive staining for cytokeratin and expression of the common endothelial markers CD31, CD34, and von Willebrand factor.

Positive_regulation (positive) of Gene_expression (expression) of CD31 associated with cancer

5) Confidence 0.11 Published 1999 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10555012 Disease Relevance 0.84 Pain Relevance 0.08

Furthermore, we found significantly elevated serum levels for sICAM-1 after PTCA and for sPECAM-1 in the tPA group compared with controls and with both of the other therapy groups.

Positive_regulation (elevated) of Gene_expression (group) of sPECAM-1 associated with percutaneous transluminal coronary angioplasty

6) Confidence 0.09 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.59 Pain Relevance 0.23

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