INT85015

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 40
Disease Relevance 30.75
Pain Relevance 10.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
muscle 2
cortex 2
Plasma 1
spike 1
eye muscles 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 902 100.00 Very High Very High Very High
Osteoarthritis 324 100.00 Very High Very High Very High
Calcitonin gene-related peptide 45 100.00 Very High Very High Very High
cytokine 21 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
Migraine 6 99.64 Very High Very High Very High
Arthritis 24 98.76 Very High Very High Very High
Inflammation 47 98.72 Very High Very High Very High
Chronic pancreatitis 21 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 902 100.00 Very High Very High Very High
Adhesions 900 100.00 Very High Very High Very High
Osteoarthritis 324 100.00 Very High Very High Very High
Hypoxia 21 100.00 Very High Very High Very High
Paralysis 30 99.86 Very High Very High Very High
Pancreatic Cancer 49 99.84 Very High Very High Very High
Adenocarcinoma 42 99.84 Very High Very High Very High
Headache 4 99.64 Very High Very High Very High
Cardiovascular Disease 10 98.80 Very High Very High Very High
Seronegative Spondarthritis 12 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All 5 evaluated pancreatic cancer cells lines expressed ADM, CRLR, RAMP1 and RAMP2, whereas RAMP3 was expressed in only 1/5 pancreatic cancer cell lines.
Gene_expression (expressed) of ADM associated with pancreatic cancer
1) Confidence 0.73 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.61 Pain Relevance 0.27
By immunohistochemistry, ADM, CRLR, RAMP1 and RAMP2, but not RAMP3, were expressed in pancreatic cancer cells.
Gene_expression (expressed) of ADM associated with pancreatic cancer
2) Confidence 0.73 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.14 Pain Relevance 0.25
Given previous evidence that RA-FLSs expressed more adrenomedullin and adrenomedullin receptors (CLR/RAMP-2 and CLR/RAMP-3) than did OA-FLS [10], we compared the effect of adrenomedullin on RA-FLSs and OA-FLSs.
Gene_expression (expressed) of adrenomedullin associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.72 Pain Relevance 0.53
Given previous evidence that RA-FLSs expressed more adrenomedullin and adrenomedullin receptors (CLR/RAMP-2 and CLR/RAMP-3) than did OA-FLS [10], we compared the effect of adrenomedullin on RA-FLSs and OA-FLSs.
Gene_expression (expressed) of adrenomedullin associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.70 Pain Relevance 0.52
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
Gene_expression (synthesized) of Adrenomedullin
5) Confidence 0.64 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.48 Pain Relevance 0
In conclusion, ADM is induced by hypoxia and over-expressed in PDAC and might therefore serve as a potential tumor marker.
Gene_expression (expressed) of ADM associated with adenocarcinoma, cancer and hypoxia
6) Confidence 0.64 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.59 Pain Relevance 0.22
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
Gene_expression (synthesized) of ADM
7) Confidence 0.64 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.48 Pain Relevance 0
In this study, the expression and functional role of ADM and its signaling components were investigated in pancreatic adenocarcinoma (PDAC).
Gene_expression (expression) of ADM associated with adenocarcinoma
8) Confidence 0.64 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.75 Pain Relevance 0.13
We found that adrenomedullin specifically increased RA-FLS adhesion to ECM proteins but had no effect on OA-FLS adhesion.
Gene_expression (adhesion) of adrenomedullin associated with rheumatoid arthritis, osteoarthritis and adhesions
9) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.48 Pain Relevance 0.98
The adhesion-enhancing effect of adrenomedullin is mediated by the adrenomedullin receptor CLR/RAMP
Gene_expression (adhesion-enhancing) of adrenomedullin associated with adhesions
10) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.94 Pain Relevance 0.60
The adhesion-enhancing effect of adrenomedullin is mediated by the adrenomedullin receptor CLR/RAMP
Gene_expression (/) of adrenomedullin associated with adhesions
11) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.92 Pain Relevance 0.60
More recently, our group reported overexpression in RA-FLSs of adrenomedullin and its CLR/RAMP-2,3 receptor mRNA and protein, compared with FLSs from OA patients (OA-FLS) [10].
Gene_expression (overexpression) of adrenomedullin associated with rheumatoid arthritis and osteoarthritis
12) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.50 Pain Relevance 0.58
This effect is mediated by the adrenomedullin receptor CLR, and it does not occur with OA-FLSs, which express fewer adrenomedullin receptors [10].
Gene_expression (express) of adrenomedullin associated with osteoarthritis
13) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.39 Pain Relevance 0.29
This difference may be ascribable to the stronger expression of adrenomedullin receptor (CLR/RAMP2) mRNA and proteins by RA-FLSs than by OA-FLSs [10].
Gene_expression (expression) of adrenomedullin associated with rheumatoid arthritis and osteoarthritis
14) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.37 Pain Relevance 0.91
Plasma adrenomedullin levels are higher in RA than in other inflammatory diseases (lupus and scleroderma), osteoarthritis (OA), and in normal individuals [11].
Gene_expression (levels) of Plasma adrenomedullin in Plasma associated with inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, disease and osteoarthritis
15) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.57 Pain Relevance 0.62
The adrenomedullin effect is specific of rheumatoid FLSs adhesion
Gene_expression (effect) of adrenomedullin associated with adhesions
16) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.61 Pain Relevance 0.49
As siRNA would inhibit not only adrenomedullin-stimulated adhesion, but also basal adhesion, we chose talin IP followed by integrin ?
Gene_expression (adhesion) of adrenomedullin-stimulated associated with adhesions
17) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.84 Pain Relevance 0.10
In the current study, the expression of mRNA for ADM and the two cloned human CGRP1 receptors (identified here as A-CGRP1 receptors [Aiyar et al., 1996] and K-CGRP1 receptors) [Kapas and Clark, 1995] were evaluated in human brain vessels and trigeminal ganglia.
Gene_expression (expression) of ADM in trigeminal ganglia
18) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10566974 Disease Relevance 0.27 Pain Relevance 0.39
By QRT-PCR, median mRNA levels of ADM and CRLR were 1.5- and 2.4-fold higher, respectively, in PDAC tissues compared to normal pancreatic tissues.
Gene_expression (levels) of ADM associated with adenocarcinoma
19) Confidence 0.49 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.93 Pain Relevance 0.21
Calcitonin gene-related peptide and adrenomedullin belong to a structurally related neuropeptide family and are potent vasodilators expressed in the trigeminovascular system.
Gene_expression (expressed) of adrenomedullin associated with neuropeptide and calcitonin gene-related peptide
20) Confidence 0.48 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.18

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