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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 62
Total Number 62
Disease Relevance 17.97
Pain Relevance 26.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neurons 8
sensory neurons 5
neuronal 4
small intestine 3
testis 3
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 88 100.00 Very High Very High Very High
sodium channel 67 100.00 Very High Very High Very High
Nav1.9 20 100.00 Very High Very High Very High
nav1.8 14 100.00 Very High Very High Very High
dorsal root ganglion 216 99.86 Very High Very High Very High
c fibre 48 99.84 Very High Very High Very High
Morphine 13 99.84 Very High Very High Very High
lidocaine 21 99.76 Very High Very High Very High
Neuropeptide 34 99.74 Very High Very High Very High
nav1.3 8 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 426 99.86 Very High Very High Very High
Immunization 11 99.46 Very High Very High Very High
Sprains And Strains 1412 99.20 Very High Very High Very High
Pain 652 99.04 Very High Very High Very High
Targeted Disruption 102 99.00 Very High Very High Very High
Neuropathic Pain 563 98.84 Very High Very High Very High
Nociception 32 96.80 Very High Very High Very High
Nervous System Injury 177 95.80 Very High Very High Very High
Pox Virus Infection 23 92.92 High High
Heart Arrhythmia 32 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaT in uterus associated with spinal cord
1) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a.
Gene_expression (expression) of Scn11a associated with tetrodotoxin and sodium channel
2) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.34
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of Scn11a in uterus associated with spinal cord
3) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
This facility is illustrated by outlier values for Gal and Scn11a expression in two ostensibly nerve injured mice, both C58.
Gene_expression (expression) of Scn11a in nerve
4) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.49 Pain Relevance 0.17
Scn11a, the gene for the TTX-R Na+ channel Nav1.9, was predominantly expressed in small and medium sized neuronal profiles in naïve mice, with only a minor percentage (highest in the CBA strain) in larger neurons.
Gene_expression (expressed) of Scn11a in neuronal associated with sprains and strains and nav1.9
5) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.34 Pain Relevance 0.53
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of SNS2 in uterus associated with spinal cord
6) Confidence 0.75 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
Cloning and expression study of the mouse tetrodotoxin-resistant voltage-gated sodium channel alpha subunit NaT/Scn11a.
Gene_expression (expression) of NaT associated with tetrodotoxin and sodium channel
7) Confidence 0.68 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.33
Scn11a, the gene for the TTX-R Na+ channel Nav1.9, was predominantly expressed in small and medium sized neuronal profiles in naïve mice, with only a minor percentage (highest in the CBA strain) in larger neurons.
Gene_expression (expressed) of Na in neuronal associated with sprains and strains and nav1.9
8) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.33 Pain Relevance 0.52
Results obtained in the TaqMan analysis of Gal and Scn11a transcripts measured in the L5DRGs of all five strains were confirmed in the microarrays.
Gene_expression (transcripts) of Scn11a associated with sprains and strains
9) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.06 Pain Relevance 0.06
For Scn11a, expression was reduced in all strains, with the degree of reduction minimal in animals that exhibited a high level of ongoing pain behavior and maximal in strains with minimal ongoing pain.
Gene_expression (expression) of Scn11a associated with pain and sprains and strains
10) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.94 Pain Relevance 0.59
Functional expression of I(NaN) declined with time after cell dissociation and recovered during culture, implying that Na(v)1.9 may be regulated dynamically by trophic factors or depend on subtle environmental factors for its survival.
Gene_expression (expression) of NaN
11) Confidence 0.57 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 15290301 Disease Relevance 0.20 Pain Relevance 0.22
-subunit Nav 1.8 [GenBank: NM_009134], (base 2980–3021), the Na+ channel ?
Gene_expression (channel) of Na
12) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.44 Pain Relevance 0.29
For Scn11a the following sequences were selected: target forward primer: GAGGAATGTGCCGCTGTCA, target reverse primer: CTTTCAGCTTCAGCTTGATCATCTT.
Gene_expression (selected) of Scn11a
13) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.06 Pain Relevance 0.03
The first two code for voltage sensitive Na+ channel ?
Gene_expression (channel) of Na
14) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.92 Pain Relevance 0.48
The NAT transgene (NAT) was inserted into a noncoding region downstream of the LYS2 gene coding region located on chromosome 5.
Gene_expression (transgene) of NAT
15) Confidence 0.53 Published 2010 Journal mBio Section Body Doc Link PMC2912664 Disease Relevance 0.26 Pain Relevance 0
The NAT transgene (NAT) was inserted into a noncoding region downstream of the LYS2 gene coding region located on chromosome 5.
Gene_expression (transgene) of NAT
16) Confidence 0.53 Published 2010 Journal mBio Section Body Doc Link PMC2912664 Disease Relevance 0.26 Pain Relevance 0
NaT is detectable in mouse embryos 15 days postcoitus (p.c.), around the phase of organogenesis and gonadal differentiation.
Gene_expression (detectable) of NaT in gonadal
17) Confidence 0.53 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.27
In conclusion, our data demonstrate that the expression of Na(v)1.8 in sensory neurons can confine the antinociceptive efficacy of lidocaine and other Na+ channel blockers employed for pain treatment.
Gene_expression (expression) of Na in sensory neurons associated with pain, lidocaine and antinociceptive
18) Confidence 0.51 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.60 Pain Relevance 1.40
Scn10a, the gene for the TTX-R Na+ channel Nav1.8, was expressed mostly in neuronal profiles of small and medium size in naïve mice.
Gene_expression (expressed) of Na in neuronal associated with nav1.8
19) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.12 Pain Relevance 0.63
The NAT gene is present only in AD 1-25, so diploid cells generated by endoreplication would have two copies, whereas those generated by cell fusion between AD 7-99 and AD 1-25 would have only a single copy.
Gene_expression (present) of NAT in diploid cells
20) Confidence 0.47 Published 2010 Journal mBio Section Body Doc Link PMC2912664 Disease Relevance 0.20 Pain Relevance 0

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