INT85537

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.64
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Anatomy Link Frequency
hypothalamus 1
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
tricyclic antidepressant 1 100.00 Very High Very High Very High
depression 9 99.60 Very High Very High Very High
withdrawal 25 99.08 Very High Very High Very High
opiate 18 98.84 Very High Very High Very High
Opioid 8 95.28 Very High Very High Very High
Dynorphin 2 94.88 High High
Morphine 24 89.72 High High
Disease Link Frequency Relevance Heat
Depression 9 99.60 Very High Very High Very High
Anxiety Disorder 25 92.56 High High
Stress 15 84.68 Quite High
Weight Loss 2 81.44 Quite High
Disorders Of The Lacrimal System 2 80.40 Quite High
Opiate Addiction 1 62.88 Quite High
Urological Neuroanatomy 4 53.68 Quite High
Aggression 55 52.60 Quite High
Targeted Disruption 16 48.40 Quite Low
Aids-related Complex 3 39.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings unravel a key role for the hypothalamus-pituitary-adrenal (HPA) system and brain extra-hypothalamic CRF/CRF1 receptor circuitry in somatic, molecular, and endocrine alterations induced by opiate withdrawal.
Regulation (role) of CRF1 in hypothalamus associated with opiate and withdrawal
1) Confidence 0.45 Published 2007 Journal Neuron Section Abstract Doc Link 17296558 Disease Relevance 0.29 Pain Relevance 0.93
Our pharmacological dissection of drug-regulated gene expression profiles showed the inhibitory effects of CRFR1 and GR antagonists on ethanol-activated gene expression of the B2 and B3 subclusters.
Regulation (effects) of CRFR1 associated with antagonist
2) Confidence 0.38 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0.41
First, the influence of a selective CRF receptor-1 (CRF-R1) antagonist, CP-154,526, on opiate withdrawal behavior was examined.
Spec (examined) Regulation (influence) of CRF receptor-1 associated with antagonist, opiate and withdrawal
3) Confidence 0.36 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617121 Disease Relevance 0.31 Pain Relevance 0.80
First, the influence of a selective CRF receptor-1 (CRF-R1) antagonist, CP-154,526, on opiate withdrawal behavior was examined.
Spec (examined) Regulation (influence) of CRF-R1 associated with antagonist, opiate and withdrawal
4) Confidence 0.36 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617121 Disease Relevance 0.31 Pain Relevance 0.83
To investigate the mechanism of IFN-alpha-induced depression-like behavior, the effects of the tricyclic antidepressant imipramine, the cyclooxygenase inhibitor indomethacin, the opioid receptor antagonist naloxone, and the selective corticotropin-releasing hormone receptor antagonist CP-154, 526 on IFN-alpha-induced depression-like behavior were evaluated.
Regulation (effects) of selective corticotropin-releasing hormone receptor associated with depression, antagonist, narcan, opioid receptor and tricyclic antidepressant
5) Confidence 0.28 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10604946 Disease Relevance 0.46 Pain Relevance 0.48
Thus, CRF acting on CRFR1 could have an inverted U-shaped effect on maternal care.
Regulation (acting) of CRFR1
6) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

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