INT85651

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 4.73
Pain Relevance 8.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACACA) mitochondrion (ACACA) small molecule metabolic process (ACACA)
ligase activity (ACACA) cytoplasm (ACACA)
Anatomy Link Frequency
ACC 7
dorsal 1
primary somatosensory cortex 1
anterior 1
thalamus 1
ACACA (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 452 100.00 Very High Very High Very High
gABA 20 100.00 Very High Very High Very High
long-term potentiation 7 100.00 Very High Very High Very High
Hippocampus 4 100.00 Very High Very High Very High
primary somatosensory cortex 1 100.00 Very High Very High Very High
cocaine 132 99.82 Very High Very High Very High
Pain 52 99.54 Very High Very High Very High
spastic colon 18 99.44 Very High Very High Very High
Glutamate 50 98.72 Very High Very High Very High
Thalamus 27 98.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 7 99.92 Very High Very High Very High
Pain 33 99.54 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

18 99.44 Very High Very High Very High
Injury 2 99.36 Very High Very High Very High
Cognitive Disorder 43 98.64 Very High Very High Very High
Congenital Anomalies 74 92.44 High High
Obsessive-compulsive Disorder 45 87.04 High High
Anxiety Disorder 72 84.64 Quite High
Drug Dependence 15 81.88 Quite High
Functional Bowel Disorder 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An anterior ACC activation was sustained throughout the 40 minutes of DBS, whereas a more posteriorly located ACC activation occurred at a delay after onset of DBS, although these activations were not dependent on the degree of pain relief reported during DBS.
Positive_regulation (activation) of ACC in anterior
1) Confidence 0.67 Published 2000 Journal J. Neurosurg. Section Body Doc Link 10616084 Disease Relevance 0.07 Pain Relevance 0
It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity.
Positive_regulation (increased) of ACC in ACC
2) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link 20509977 Disease Relevance 0 Pain Relevance 0
Recent findings suggest that while ACC LTP in brain slice preparations is postsynaptically induced and expressed, injury triggered synaptic potentiation in the ACC contains both presynaptic enhancement of glutamate release and postsynaptic potentiation of AMPA receptor-mediated responses.
Positive_regulation (induced) of ACC in ACC associated with glutamate, injury, long-term potentiation and anterior cingulate cortex
3) Confidence 0.67 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.44 Pain Relevance 0.97
CONCLUSIONS: A possible explanation for the neuropathic pain-related suppression of EPSPs is that the ACC was already sufficiently active at baseline as a result of neuropathic pain, and ATN stimulation could not further increase the already elevated level of ACC activity.
Neg (not) Positive_regulation (increase) of ACC in ACC
4) Confidence 0.67 Published 2008 Journal Brain Res. Section Body Doc Link 18786516 Disease Relevance 0.07 Pain Relevance 0
In IBS patients, not in controls, ACC and HC were also activated by auditory stimulation.
Positive_regulation (activated) of ACC in ACC associated with spastic colon, hippocampus and anterior cingulate cortex
5) Confidence 0.67 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16336498 Disease Relevance 0.20 Pain Relevance 1.15
Furthermore, first pain appears to be particularly related to activation of S1 whereas second pain is closely related to ACC activation.
Positive_regulation (activation) of ACC in ACC associated with pain and anterior cingulate cortex
6) Confidence 0.67 Published 2004 Journal Nervenarzt Section Abstract Doc Link 15184984 Disease Relevance 1.00 Pain Relevance 1.07
ACC transplantation may be upregulated by the use of three-dimensional (3-D) scaffolds.
Spec (may) Positive_regulation (upregulated) of ACC
7) Confidence 0.67 Published 2003 Journal Tissue Eng. Section Abstract Doc Link 14633388 Disease Relevance 0.19 Pain Relevance 0.23
Increased ACC activity was observed in IBS patients with no history of abuse (Z = 5.2, P < 0.001) similar to controls, whereas no such increased activity was noticed in the abused group.
Positive_regulation (Increased) of ACC in ACC associated with spastic colon and anterior cingulate cortex
8) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14561000 Disease Relevance 0.14 Pain Relevance 0.89
In contrast to ACC 24b, the primary somatosensory cortex showed significant activations in response to both noxious and innocuous tactile, but not visual, stimuli.
Positive_regulation (activations) of ACC in primary somatosensory cortex associated with primary somatosensory cortex and anterior cingulate cortex
9) Confidence 0.49 Published 2004 Journal Cogn Affect Behav Neurosci Section Abstract Doc Link 15460933 Disease Relevance 0.26 Pain Relevance 0.72
ACC activation in study one predicted ventral striatum activation in study two.
Positive_regulation (activation) of ACC in ACC associated with anterior cingulate cortex
10) Confidence 0.45 Published 2009 Journal Science Section Abstract Doc Link 19213918 Disease Relevance 0.15 Pain Relevance 0.43
Group comparisons showed that activation was higher for controls than for cocaine abusers in the dorsolateral PFC (MFG BA 9, and precentral gyrus BA 6), cerebellum, thalamus, and left caudate (pcorr <0.05; Fig. 5A and Table 2); cocaine abusers deactivated more the rACC than controls (pcorr <0.05; Fig. 5A and Table 2).
Positive_regulation (deactivated) of rACC in thalamus associated with thalamus and cocaine
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2876035 Disease Relevance 0 Pain Relevance 0.51
The reason behind this discrepancy is that the Acetyl-CoA requirement for biosynthetic routes, especially for lipid metabolism, was ignored in those studies although significant molar amount is needed for cholesterol (r136) and fatty acid (r138–r140, r143–r145) syntheses.
Positive_regulation (requirement) of Acetyl-CoA in molar
12) Confidence 0.04 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0 Pain Relevance 0
Group comparisons showed that activation was higher for controls than for cocaine abusers in the dorsolateral PFC (MFG BA 9, and precentral gyrus BA 6), cerebellum, thalamus, and left caudate (pcorr <0.05; Fig. 5A and Table 2); cocaine abusers deactivated more the rACC than controls (pcorr <0.05; Fig. 5A and Table 2).
Positive_regulation (deactivated) of rACC in cerebellum associated with thalamus and cocaine
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2876035 Disease Relevance 0 Pain Relevance 0.51
Compared to non-painful stimulation, painful tonic heat was associated with a significant increase in GABA concentrations in the rACC.
Positive_regulation (increase) of rACC associated with pain and gaba
14) Confidence 0.02 Published 2009 Journal Pain Section Abstract Doc Link 19167811 Disease Relevance 0.23 Pain Relevance 1.62
Compared with controls, ASD participants showed increased rACC activation to both correct and error responses and reduced microstructural integrity of the WM underlying ACC, including in regions showing abnormally increased response monitoring activation.
Positive_regulation (activation) of rACC associated with anterior cingulate cortex
15) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.09 Pain Relevance 0.16
Finally, it is dorsal rather than rACC activation that is associated with engaging cognitive control on correct high-conflict and error trials (Carter and van Veen, 2007).
Positive_regulation (activation) of rACC in dorsal associated with cognitive disorder
16) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.10 Pain Relevance 0.11
This provides a plausible explanation for the relation between increased rACC activity to correct trials and repetitive behaviour.
Positive_regulation (increased) of rACC
17) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.34 Pain Relevance 0.06
Moreover, in rACC increased activation to correct trials and reduced FA were related to ratings of rigid, repetitive behaviour.
Positive_regulation (increased) of rACC
18) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.08 Pain Relevance 0.15
In summary, the present study reports hyperactive response monitoring in the rACC in ASD that is related to restricted, repetitive behaviour and is accompanied by reduced FA in the underlying white matter.
Positive_regulation (accompanied) of rACC in white matter
19) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.15 Pain Relevance 0.04

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