INT85759

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Context Info
Confidence 0.55
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
muscles 1
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 65 97.76 Very High Very High Very High
Glutamate 5 36.64 Quite Low
antagonist 4 30.16 Quite Low
agonist 7 18.52 Low Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Aging 38 88.64 High High
Tuberous Sclerosis 1 45.84 Quite Low
Frailty 5 14.20 Low Low
Apoptosis 23 9.56 Low Low
Death 8 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, PCLS obtained from Gd+ rats exhibited a lower release of tumor necrosis factor (TNF-alpha) and a better viability than PCLS from control (Gd-) rats.
Localization (release) of factor associated with necrosis and cancer
1) Confidence 0.55 Published 1999 Journal Life Sci. Section Abstract Doc Link 10622274 Disease Relevance 0.20 Pain Relevance 0.42
Using an ex vivo approach resulted in a similar conclusion as the aged control muscles required higher levels of Akt phosphorylation (both Ser474 and Thr308) to phosphorylate similar amounts of GSK3?
Localization (amounts) of GSK3 in muscles
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.23 Pain Relevance 0.10
Histograms represent the percentage increase with respect to non-stimulated cells (100% control value), and were obtained by normalization of densitometric values of phospho-proteins with respect to total forms of GSK3.
Localization (forms) of GSK3
3) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0

General Comments

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