INT85861

Context Info Confidence 0.21 First Reported 2000 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.33 Pain Relevance 0.66

molecular_function (Abpe) cellular_component (Abpe) biological_process (Abpe)

Anatomy Link Frequency lacrimal 5 lacrimal gland 1 Abpe (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 15 99.46 adenocard 5 97.54 Inflammation 5 5.00 metalloproteinase 2 5.00 chemokine 2 5.00 antagonist 2 5.00 Spinal cord 1 5.00 fibrosis 1 5.00 Cholecystokinin 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Disorders Of The Lacrimal System 95 100.00 Eyelid Disease 2 82.08 INFLAMMATION 5 5.00 Dry Eye 4 5.00 Autoimmune Disease 2 5.00 Syndrome 2 5.00 Acne 1 5.00 Androgen Insensitivity 1 5.00 Aging 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Androgens are known to exert a tremendous impact on the structure and function of the lacrimal gland, including such aspects as the cellular morphology, nuclear architecture, protein synthesis, enzyme activity, receptor expression and fluid and protein secretion [28].

Localization (secretion) of lacrimal in lacrimal gland associated with disorders of the lacrimal system

1) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.91 Pain Relevance 0

In separate experiments, cells were pretreated with pertussis toxin or polyclonal antibodies against the alpha subunits of Gi/Go to determine the physiologic role of G proteins in met-enkephalin inhibition of the release of lacrimal protein.

Localization (release) of lacrimal in lacrimal

2) Confidence 0.02 Published 2000 Journal Cornea Section Body Doc Link 10632016 Disease Relevance 0.08 Pain Relevance 0

RESULTS: Cch resulted in a significant increase in protein release from cultured lacrimal acini.

Localization (release) of lacrimal in lacrimal

3) Confidence 0.01 Published 2000 Journal Cornea Section Body Doc Link 10632016 Disease Relevance 0.07 Pain Relevance 0

PURPOSE: To determine whether G-protein-mediated inhibition of secretion by met-enkephalin involves cyclic adenosine monophosphate (cAMP)-dependent events and to identify the G proteins that couple met-enkephalin to inhibition of lacrimal secretion.

Localization (secretion) of lacrimal in lacrimal associated with disorders of the lacrimal system, adenocard and enkephalin

4) Confidence 0.01 Published 2000 Journal Cornea Section Abstract Doc Link 10632016 Disease Relevance 0.17 Pain Relevance 0.32

However, we suggest a role for met-enkephalin in G-protein-coupled modulation of ion channels important for cholinergic and beta-adrenergic stimulation of lacrimal secretion.

Localization (secretion) of lacrimal in lacrimal

5) Confidence 0.01 Published 2000 Journal Cornea Section Body Doc Link 10632016 Disease Relevance 0 Pain Relevance 0

Gi/Go couple met-enkephalin to inhibition of cholinergic and beta-adrenergic stimulation of lacrimal secretion.

Localization (secretion) of lacrimal in lacrimal associated with disorders of the lacrimal system and enkephalin

6) Confidence 0.01 Published 2000 Journal Cornea Section Title Doc Link 10632016 Disease Relevance 0.10 Pain Relevance 0.34

General Comments

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