INT85869

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.49
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
nucleus 2
nerve 1
T cells 1
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 47 99.32 Very High Very High Very High
dorsal root ganglion 4 99.08 Very High Very High Very High
Hyperalgesia 3 95.04 Very High Very High Very High
Pain 3 94.40 High High
cytokine 25 91.88 High High
rheumatoid arthritis 3 87.08 High High
Potency 2 66.72 Quite High
psoriasis 14 60.08 Quite High
Inflammatory mediators 5 55.80 Quite High
methotrexate 55 50.00 Quite Low
Disease Link Frequency Relevance Heat
Myocarditis 3 99.32 Very High Very High Very High
Ganglion Cysts 4 98.60 Very High Very High Very High
Acute Myocarditis 30 98.04 Very High Very High Very High
Hyperalgesia 3 95.04 Very High Very High Very High
Pain 3 94.40 High High
Heart Rate Under Development 20 93.92 High High
INFLAMMATION 51 91.52 High High
Sepsis 1 87.64 High High
Rheumatoid Arthritis 3 87.08 High High
Disease 11 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Transcription (expression) of IL-2 in T cells
1) Confidence 0.23 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
This process prevents translocation to the nucleus of the cytoplasmic component of the nuclear factor of activated T cells (NFAT), which in turn impairs transcription of the genes encoding interleukin-2 (IL-2) and other lymphokines (Schreiber and Crabtree 1992; Ho et al 1996).
Transcription (transcription) of interleukin-2 in nucleus
2) Confidence 0.16 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699819 Disease Relevance 0.12 Pain Relevance 0.10
This process prevents translocation to the nucleus of the cytoplasmic component of the nuclear factor of activated T cells (NFAT), which in turn impairs transcription of the genes encoding interleukin-2 (IL-2) and other lymphokines (Schreiber and Crabtree 1992; Ho et al 1996).
Transcription (transcription) of IL-2 in nucleus
3) Confidence 0.16 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699819 Disease Relevance 0.12 Pain Relevance 0.10
Intraperitoneal administration of recombinant human IL-10 into mice with experimental viral myocarditis appeared to improve survival, attenuate myocardial inflammation and decrease the myocardial mRNA expression of TNF- alpha, IL-2, and inducible NO synthase [9].
Transcription (expression) of IL-2 associated with myocarditis, inflammation and acute myocarditis
4) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 1.90 Pain Relevance 0.45
The purpose of this study was to examine whether mRNA of interleukin-A2, interleukin-6, phospholipase A2, and nitric oxide synthase was expressed in the nerve root and dorsal root ganglion of an animal model in which exposure to the nucleus pulposus induced mechanical hyperalgesia, a pain-related behavior.
Transcription (expressed) of interleukin-A2 in nerve associated with ganglion cysts, pain, dorsal root ganglion and hyperalgesia
5) Confidence 0.06 Published 1999 Journal J. Orthop. Res. Section Abstract Doc Link 10632462 Disease Relevance 0.36 Pain Relevance 0.30

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