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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 50
Total Number 50
Disease Relevance 30.90
Pain Relevance 9.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Anatomy Link Frequency
T cells 15
platelets 8
microglia 2
astrocytes 2
dendritic cells 1
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 61 99.08 Very High Very High Very High
cva 20 98.56 Very High Very High Very High
Arthritis 107 98.52 Very High Very High Very High
tolerance 86 98.52 Very High Very High Very High
chemokine 35 98.36 Very High Very High Very High
Inflammation 514 98.20 Very High Very High Very High
cytokine 300 98.00 Very High Very High Very High
Angina 45 97.88 Very High Very High Very High
Inflammatory response 32 97.84 Very High Very High Very High
Pain 14 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 12 99.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 174 99.54 Very High Very High Very High
Atherosclerotic Plaque 7 99.52 Very High Very High Very High
Thrombosis 59 99.38 Very High Very High Very High
Disease 545 99.28 Very High Very High Very High
Systemic Lupus Erythematosus 66 99.12 Very High Very High Very High
Encephalitis 16 99.08 Very High Very High Very High
Amyloid Plaque 29 99.04 Very High Very High Very High
Injury 24 98.92 Very High Very High Very High
Adhesions 20 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In platelets isolated from normal subjects, the expression of CD40L was not detected in all subjects.
Gene_expression (expression) of CD40L in platelets
1) Confidence 0.73 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 1.07 Pain Relevance 0.28
To investigate the activation status of platelets in coronary artery disease patients, we tested expression levels of CD40L, and platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in platelets isolated from peripheral blood, using flow cytometric analysis.
Gene_expression (expression) of CD40L in platelets associated with coronary artery disease and adhesions
2) Confidence 0.73 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.90 Pain Relevance 0.21
These data indicate that the rupture of plaque and subsequent formation of thrombus may lead to the activation of CD40L expression in circulating platelets of ACS patients.
Gene_expression (expression) of CD40L in platelets associated with rupture and thrombosis
3) Confidence 0.73 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.90 Pain Relevance 0.23
Recently, CD40L expression was found in activated platelets in the thrombus in vivo and CD40L was reported to be responsible for the platelet-mediated activation of endothelial cells in vitro.
Gene_expression (expression) of CD40L in platelets associated with thrombosis
4) Confidence 0.73 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.66 Pain Relevance 0.11
It has been demonstrated that overexpression of CD154 (CD40L) on T cells correlates with higher disease activity [5], which is confirmed by studies showing treatment of mice with agonistic anti-CD40 Abs at the time of CIA induction exacerbates disease [6].
Gene_expression (overexpression) of CD40L in T cells associated with disease and arthritis
5) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.20 Pain Relevance 0.52
It has been demonstrated that overexpression of CD154 (CD40L) on T cells correlates with higher disease activity [5], which is confirmed by studies showing treatment of mice with agonistic anti-CD40 Abs at the time of CIA induction exacerbates disease [6].
Gene_expression (overexpression) of CD154 in T cells associated with disease and arthritis
6) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.15 Pain Relevance 0.49
Despite promising preclinical data, translation of CD40/154 blockade approaches has proved difficult due to the expression of CD154 on platelets, which causes risk of thromboembolic events.
Gene_expression (expression) of CD154 in platelets associated with cva
7) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.81 Pain Relevance 0.30
Memory phenotype CD4+ T cells and effector cells express very different levels of CD40L ([48], [57] and data not shown).
Gene_expression (express) of CD40L in T cells
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.37 Pain Relevance 0.03
In addition, the mRNA expression of inducible nitric oxide synthase (iNOS), CD40 ligand, Interferon-gamma-inducible protein 10 (IP-10), and the proinflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta, and IL-6, which were elevated with Tat alone, were dramatically enhanced with Tat in the presence of morphine.
Gene_expression (expression) of CD40 ligand associated with necrosis, cancer, morphine and cytokine
9) Confidence 0.58 Published 2009 Journal J. Neurovirol. Section Abstract Doc Link 19462331 Disease Relevance 0.94 Pain Relevance 0.83
To investigate the activation status of platelets in coronary artery disease patients, we tested expression levels of CD40L, and platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in platelets isolated from peripheral blood, using flow cytometric analysis.
Gene_expression (levels) of CD40L in platelets associated with coronary artery disease and adhesions
10) Confidence 0.57 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.90 Pain Relevance 0.21
CD40L and CD62P expression on platelets and platelet-monocyte aggregates were measured by flow cytometry.
Gene_expression (expression) of CD40L in monocyte
11) Confidence 0.54 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16182391 Disease Relevance 0.16 Pain Relevance 0
CD40L expression on platelets in patients with unstable angina was significantly higher in arterial and coronary blood compared to patients with stable angina.
Gene_expression (expression) of CD40L in platelets
12) Confidence 0.54 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16182391 Disease Relevance 0.12 Pain Relevance 0
CD40L blockade does not prevent the induction of autoimmune diabetes by memory-like T cells
Gene_expression (blockade) of CD40L in T cells associated with diabetes mellitus
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.47 Pain Relevance 0.20
Interestingly, we could not document any increase in CD154 (the CD40 ligand) on T cells, and therefore decided not to include CD154 in our standard panel.
Gene_expression (ligand) of CD154 in T cells
14) Confidence 0.51 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.27 Pain Relevance 0.03
CD40L is a key immunoregulatory molecule that plays a co-stimulatory role in the activation of immune cells from both the innate and adaptive arms of the immune system, and is typically expressed by activated CD4+ and some CD8+ T cell subsets [49].
Gene_expression (expressed) of CD40L in immune system
15) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.04 Pain Relevance 0.15
plus CD40L stimulation, we examined innate and adaptive activation of murine microglia challenged with A?
Gene_expression (stimulation) of CD40L in microglia
16) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.06 Pain Relevance 0.11
plus CD40L pre-treatment of microglia resulted in markedly enhanced levels of the Th1-promoting cytokines IL-6, TNF-?
Gene_expression (pre) of CD40L in microglia associated with cytokine
17) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.13 Pain Relevance 0.31
Furthermore, the CD40-CD40L dyad is potentiated, as can be seen from the increased numbers of CD40-positive microglial cells as well as increased CD40L expression on astrocytes in AD [53,54].
Gene_expression (expression) of CD40L in astrocytes associated with disease
18) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.82 Pain Relevance 0.33
Furthermore, the CD40-CD40L dyad is potentiated, as can be seen from the increased numbers of CD40-positive microglial cells as well as increased CD40L expression on astrocytes in AD [53,54].
Gene_expression (expression) of CD40L in astrocytes associated with disease
19) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.79 Pain Relevance 0.31
This well characterized mAb has been extensively used to block CD40 engagement by CD40L expressing cells.
Gene_expression (expressing) of CD40L
20) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.33 Pain Relevance 0.03

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