INT86063

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.34
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
sciatic nerve 2
Schwann cells 2
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 23 99.98 Very High Very High Very High
Eae 8 98.92 Very High Very High Very High
Sciatic nerve 11 98.48 Very High Very High Very High
Pain 6 89.24 High High
Peripheral nerve injury 2 84.08 Quite High
metalloproteinase 16 83.88 Quite High
cva 3 76.68 Quite High
Inflammation 6 36.72 Quite Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 15 99.98 Very High Very High Very High
Injury 17 98.92 Very High Very High Very High
Adhesions 18 87.76 High High
Nervous System Injury 4 84.08 Quite High
Stroke 25 81.48 Quite High
Neuropathic Pain 2 77.20 Quite High
Hemorrhage 5 76.68 Quite High
Apoptosis 5 67.00 Quite High
Disease 5 62.68 Quite High
Increased Venous Pressure Under Development 9 59.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The densitometric analysis revealed also that intra-peritoneal minocycline 45 mg/kg treatment twice a day (first dose immediately after reperfusion), significantly reduced the ischemia-induced increments in both MMP-2 and MMP-9 active gelatinolytic forms (n = 6 for control and 8 for treated animals) (p < 0.0003) (Fig. 2).
Positive_regulation (induced) of Positive_regulation (increments) of MMP-9 associated with ischemia
1) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.61 Pain Relevance 0.20
This peak in TNF-alpha protein expression corresponds to an increase in gelatinase B (MMP-9) activity, which is greatly upregulated as early as 3 h following CCI to rat sciatic nerve.
Positive_regulation (upregulated) of Positive_regulation (increase) of gelatinase B in sciatic nerve associated with eae and sciatic nerve
2) Confidence 0.35 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650133 Disease Relevance 1.12 Pain Relevance 0.89
In addition, zymography showed that the enzyme activity of extracellular matrix regulating protein (MMP 9) and the migration of Schwann cells were increased after danshen and tanshinone IIA treatment.
Positive_regulation (increased) of Positive_regulation (activity) of MMP 9 in Schwann cells
3) Confidence 0.19 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.30 Pain Relevance 0.04
Monocrotaline treatment for four weeks caused an upregulation of the gelatinases MMP 2 and MMP 9 by a factor of 3.39 ± 0.65 and 3.92 ± 0.77, respectively.
Positive_regulation (caused) of Positive_regulation (upregulation) of MMP 9
4) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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