INT86088

Context Info Confidence 0.04 First Reported 2000 Last Reported 2000 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.49

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1) transcription factor binding (Foxm1) cytoplasm (Foxm1)

Anatomy Link Frequency cortex 2 Foxm1 (Mus musculus) Crygs (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 2 99.66 Serotonin 5 92.40 Cannabinoid 2 80.48 Neuropeptide 1 79.12 agonist 2 71.84 Cannabinoid receptor 4 71.52 antagonist 1 63.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

WIN 55,212-2 (1 microM) inhibited the electrically evoked tritium overflow from mouse brain cortex slices preincubated with [3H]choline by 49%. [3H]WIN 55,212-2 binding to mouse cortex membranes was inhibited by CP-55,940, SR 141716 and WIN 55,212-2 (pKi=9.30, 8.70 and 8.19, respectively) but not by the auxiliary drugs indalpine, metitepine and tetrodotoxin (pKi<4.5). [35S]GTPgammaS binding was increased by WIN 55,212-2 (maximum effect of 80%, pEC50=6.94) but not affected by WIN 55,212-3.

WIN Neg (not) Positive_regulation (increased) of GTPgammaS Binding (binding) of in cortex associated with tetrodotoxin

1) Confidence 0.04 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651142 Disease Relevance 0 Pain Relevance 0.49

General Comments

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