INT86127

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.35
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (Safb) RNA binding (Safb) nucleus (Safb)
DNA binding (Safb)
Anatomy Link Frequency
myotubes 2
uterine 1
Safb (Mus musculus)
Safb - R163C (3)
Pain Link Frequency Relevance Heat
Dismenorea 1 98.88 Very High Very High Very High
amygdala 51 97.28 Very High Very High Very High
gABA 24 96.32 Very High Very High Very High
agonist 15 87.60 High High
GABAergic 16 79.64 Quite High
addiction 41 73.24 Quite High
alcohol 11 42.24 Quite Low
withdrawal 5 35.04 Quite Low
opiate 1 34.12 Quite Low
Neurotransmitter 4 8.96 Low Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 1 98.88 Very High Very High Very High
Malignant Hyperthermia 45 97.20 Very High Very High Very High
Cancer 1 86.08 High High
Anxiety Disorder 5 71.24 Quite High
Recurrence 1 40.40 Quite Low
Stress 2 39.40 Quite Low
Alcohol Addiction 8 35.04 Quite Low
Contracture 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parameters such as normal mammary gland growth and uterine adenomyosis on which neither HAP nor CC had an effect also did not respond to HAP + CC.
Neg (not) Positive_regulation (respond) of HAP in uterine associated with dismenorea
1) Confidence 0.50 Published 1999 Journal In Vivo Section Abstract Doc Link 10654190 Disease Relevance 0.18 Pain Relevance 0.10
In this study, we observed hyperpolarizing shifts in L-type current activation for both R163C Het and Hom (?
Positive_regulation (activation) of Het (R163C)
2) Confidence 0.21 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.10 Pain Relevance 0.04
However, CRF superfusion still elicited a significant but smaller increase of IPSP amplitude in the HET mice, suggesting a different contribution of AC7 pathway to CRF vs ethanol effects.
Positive_regulation (increase) of HET
3) Confidence 0.15 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.07 Pain Relevance 0.50
At least superficially, there also appears to be a discrepancy between the whole cell measurements of L-type Ca2+ current and the small enhancement in extracellular Ca2+ entry in R163C Het and Hom myotubes inferred from Ca2+ transients in response to K+ depolarization (Fig. 5 of Estève et al., 2010) because there was actually a small reduction in the maximal amplitude of whole cell Ca2+ currents in Het and Hom myotubes (Fig. 3).
Positive_regulation (enhancement) of Het (R163C) in myotubes
4) Confidence 0.13 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0
It also seems reasonable that although there is a hyperpolarizing shift in the activation of L-type current in R163C Het and Hom myotubes (Fig. 3), this shift is less than that for the Q-V relationship because the activation of the L-type current depends not only on the movement of Q, but also on that of an additional charge (“q” in Fig. 6).
Positive_regulation (activation) of Het (R163C) in myotubes
5) Confidence 0.06 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0.04

General Comments

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