INT86292

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.09
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
colon 2
extracellular matrix 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 100.00 Very High Very High Very High
Hyperalgesia 9 97.88 Very High Very High Very High
palliative 43 96.92 Very High Very High Very High
Inflammation 6 82.64 Quite High
IPN 1 75.00 Quite High
COX-2 inhibitor 10 71.44 Quite High
chemokine 1 60.44 Quite High
Morphine 1 56.08 Quite High
cINOD 19 51.60 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 9 97.88 Very High Very High Very High
Hepatocellular Cancer 58 95.32 Very High Very High Very High
Cancer 117 92.52 High High
Adhesions 3 92.12 High High
Pancreatic Cancer 84 85.80 High High
Apoptosis 45 84.96 Quite High
Metastasis 29 83.76 Quite High
INFLAMMATION 7 82.64 Quite High
Inflammatory Pain 1 75.00 Quite High
Death 5 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lower TIMP2 levels might cause MMP2 activation, which resulted in degradation of the extracellular matrix and increased angiogenesis.
Spec (might) Positive_regulation (cause) of Spec (might) Positive_regulation (activation) of MMP2 in extracellular matrix
1) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.04 Pain Relevance 0.51
Zymography showed that ET and saline injected paws elicited increased gelatinase activity by 9 h after injection.
Positive_regulation (elicited) of Positive_regulation (increased) of gelatinase
2) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.70 Pain Relevance 0.72
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Positive_regulation (increased) of Positive_regulation (activation) of metalloproteinase-2 associated with metalloproteinase
3) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.93 Pain Relevance 0.09
activation of MMP -2, -3, -9, -14 are induced in rat colon after abdominal
Positive_regulation (induced) of Positive_regulation (activation) of MMP -2 in colon
4) Confidence 0.03 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.41 Pain Relevance 0.08

General Comments

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