INT8631

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.33
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
substantia nigra 2
sciatic nerves 1
nodes 1
brain 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 100.00 Very High Very High Very High
Pain 6 99.92 Very High Very High Very High
Nerve growth factor 8 99.90 Very High Very High Very High
Sciatic nerve 2 99.84 Very High Very High Very High
Nicotine 34 99.78 Very High Very High Very High
Ventral tegmentum 45 99.40 Very High Very High Very High
Morphine 18 98.32 Very High Very High Very High
Demyelination 4 98.24 Very High Very High Very High
cocaine 19 97.48 Very High Very High Very High
Neuritis 3 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High
Pain 5 99.92 Very High Very High Very High
Disease 5 99.14 Very High Very High Very High
Demyelinating Disease 7 98.24 Very High Very High Very High
Experimental Autoimmune Neuritis 3 97.56 Very High Very High Very High
Rheumatoid Arthritis 3 90.88 High High
Drug Dependence 1 89.72 High High
Hypoxia 10 88.68 High High
Stress 10 87.52 High High
Nociception 9 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic nicotine treatment reduced NF-160 and NF-200 immunoreactivity by 44.5% (P<0.01) and 22.5% (P<0. 05), respectively, in the ventral tegmental area but not in the substantia nigra.
Negative_regulation (reduced) of NF-200 in substantia nigra associated with ventral tegmentum, substantia nigra and nicotine
1) Confidence 0.42 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10771021 Disease Relevance 0 Pain Relevance 0.74
Chronic nicotine treatment reduced NF-160 and NF-200 immunoreactivity by 44.5% (P<0.01) and 22.5% (P<0. 05), respectively, in the ventral tegmental area but not in the substantia nigra.
Negative_regulation (reduced) of NF-160 in substantia nigra associated with ventral tegmentum, substantia nigra and nicotine
2) Confidence 0.42 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10771021 Disease Relevance 0 Pain Relevance 0.74
Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis.
Negative_regulation (Disruption) of neurofascin in nodes associated with demyelination, experimental autoimmune neuritis and neuritis
3) Confidence 0.42 Published 2009 Journal Brain Section Title Doc Link 18953054 Disease Relevance 0.82 Pain Relevance 0.34
The aim of this study was to clarify the submicroscopic basis of decreased immunoreactivity for NF-68, NF-160 and NF-200, as determined by using NR4, BF10 and RT97 antibodies, respectively.
Negative_regulation (decreased) of NF-200
4) Confidence 0.39 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.56
The aim of this study was to clarify the submicroscopic basis of decreased immunoreactivity for NF-68, NF-160 and NF-200, as determined by using NR4, BF10 and RT97 antibodies, respectively.
Negative_regulation (decreased) of NF-68
5) Confidence 0.39 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.53
The aim of this study was to clarify the submicroscopic basis of decreased immunoreactivity for NF-68, NF-160 and NF-200, as determined by using NR4, BF10 and RT97 antibodies, respectively.
Negative_regulation (decreased) of NF-160
6) Confidence 0.39 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.53
Thus, decreased NF levels in the VTA in response to chronic morphine and chronic cocaine could lead to drug-induced alterations in the structural and functional properties of this brain region, which may represent, in turn, part of a common biochemical basis of morphine and cocaine addiction and craving.
Negative_regulation (decreased) of NF in brain associated with addiction, ventral tegmentum, cocaine and morphine
7) Confidence 0.38 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.18 Pain Relevance 1.01
Significant calpain-mediated breakdown of NF160 and NF200 indicates structural damage to the axonal cytoskeleton, which was completely Ca(2+)-dependent.
Negative_regulation (breakdown) of NF200
8) Confidence 0.18 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133577 Disease Relevance 0.35 Pain Relevance 0.11
Significant calpain-mediated breakdown of NF160 and NF200 indicates structural damage to the axonal cytoskeleton, which was completely Ca(2+)-dependent.
Negative_regulation (breakdown) of NF160
9) Confidence 0.18 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133577 Disease Relevance 0.35 Pain Relevance 0.11
Inhibitors of MAP-kinases and NF-?
Negative_regulation (Inhibitors) of NF
10) Confidence 0.17 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.72 Pain Relevance 0.55
whereas NGF and NF-3 are impaired in sciatic nerves of the BB/Wor-rat but not
Negative_regulation (impaired) of NF-3 in sciatic nerves associated with nerve growth factor and sciatic nerve
11) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.14 Pain Relevance 0.21
Despite their differences, a common feature of many anti-inflammatory and disease-modifying anti-rheumatic drugs (DMARD) is inhibition of pro-inflammatory transcription factors, particularly nuclear factor (NF)-kappaB and activator protein (AP)-1. 2.
Negative_regulation (inhibition) of NF associated with inflammation and disease
12) Confidence 0.01 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10744338 Disease Relevance 0.76 Pain Relevance 0.28

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