INT86332

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.40
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FCAMR)
Anatomy Link Frequency
PNS 1
FCAMR (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 3 100.00 Very High Very High Very High
Neuritis 9 99.48 Very High Very High Very High
Adalimumab 146 99.06 Very High Very High Very High
dexamethasone 4 64.16 Quite High
aspirin 6 60.92 Quite High
Inflammation 38 57.68 Quite High
cytokine 14 22.36 Low Low
rheumatoid arthritis 22 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 9 99.48 Very High Very High Very High
Syndrome 1 98.76 Very High Very High Very High
Immunization 2 96.16 Very High Very High Very High
Recurrence 4 75.28 Quite High
INFLAMMATION 44 57.68 Quite High
Necrosis 8 50.00 Quite Low
Cancer 8 50.00 Quite Low
Repression 4 39.48 Quite Low
Obesity 4 13.08 Low Low
Increased Venous Pressure Under Development 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EAN induced in Lewis rats by inoculation with the PNS P2 protein peptide 57-81 and FCA was strongly suppressed by Rolipram administered twice daily intraperitoneally from day 9 post immunization (p.i.), i.e. after onset of clinical EAN.
FCA Binding (inoculation) of in PNS associated with peripheral nervous system, immunization and neuritis
1) Confidence 0.36 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670428 Disease Relevance 1.29 Pain Relevance 0.87
R [29,40], and binding of the Fc fragment to Fc?
Fc fragment Binding (binding) of
2) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.06 Pain Relevance 0.22
R activates NADPH oxidase [30,41], the mechanism by which adalimumab increases membrane expression of CD36 appears independent of its Fc fragment.
Fc fragment Binding (independent) of associated with adalimumab
3) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.05 Pain Relevance 0.24

General Comments

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