INT86426

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 16
Total Number 22
Disease Relevance 10.86
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
myometrium 2
muscle 2
brain 2
TMJ 2
neuronal 2
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
bDMF 16 99.88 Very High Very High Very High
dorsal root ganglion 18 99.46 Very High Very High Very High
Snapping jaw 9 98.80 Very High Very High Very High
Dismenorea 9 95.56 Very High Very High Very High
fibrosis 1 94.12 High High
withdrawal 6 93.44 High High
Paracetamol 1 92.76 High High
Peripheral nerve injury 4 91.68 High High
Inflammation 33 87.64 High High
Disease Link Frequency Relevance Heat
Shock 49 100.00 Very High Very High Very High
Injury 154 99.88 Very High Very High Very High
Targeted Disruption 12 99.84 Very High Very High Very High
Contusions 31 99.74 Very High Very High Very High
Ganglion Cysts 25 99.46 Very High Very High Very High
Apoptosis 143 99.08 Very High Very High Very High
Temporomandibular Joint Syndrome 9 98.80 Very High Very High Very High
Dysmenorrhea 9 95.56 Very High Very High Very High
Cirrhosis 1 94.12 High High
Nervous System Injury 7 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, phosphorylated Hsp27 in longitudinal muscle was primarily detected in myocyte membranes on days 15 to 22, and then also became detectable in the cytoplasm of myocytes on days 23 and PP.
Gene_expression (detected) of Hsp27 in myocytes
1) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.18 Pain Relevance 0
Immunocytochemical analysis of Ser-15 phosphorylated Hsp27 expression in situ demonstrated that phosphorylated Hsp27 in circular muscle became detectable in peri-nuclear and membrane regions on days 19 to 22, but was primarily restricted to the cytoplasm on days 23 to PP.
Gene_expression (expression) of Hsp27 in muscle
2) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.26 Pain Relevance 0.06
Immunocytochemical analysis of Ser-15 phosphorylated Hsp27 expression in situ demonstrated that phosphorylated Hsp27 in circular muscle became detectable in peri-nuclear and membrane regions on days 19 to 22, but was primarily restricted to the cytoplasm on days 23 to PP.
Gene_expression (detectable) of Hsp27 in muscle
3) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.25 Pain Relevance 0.06
Since phosphorylation of Hsp27 has been reported to be a prerequisite for smooth muscle contraction, we examined the temporal and spatial expression of Ser-15 phosphorylated Hsp27.
Spec (examined) Gene_expression (expression) of Hsp27 in smooth muscle
4) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.29 Pain Relevance 0.07
Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour.
Gene_expression (expression) of Hsp27 in myometrium associated with shock
5) Confidence 0.78 Published 2005 Journal Reproduction Section Title Doc Link 15615903 Disease Relevance 0.38 Pain Relevance 0.10
As a result, we hypothesized that Hsp27 expression would be highly induced during late pregnancy and labour.
Gene_expression (expression) of Hsp27
6) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.35 Pain Relevance 0.09
Our results demonstrate that Hsp27 expression is highly upregulated during late pregnancy and labour and suggest that Hsp27 is a potential candidate contraction-associated protein.
Gene_expression (expression) of Hsp27
7) Confidence 0.78 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.07 Pain Relevance 0
Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour.
Gene_expression (expression) of heat shock protein 27 in myometrium associated with shock
8) Confidence 0.78 Published 2005 Journal Reproduction Section Title Doc Link 15615903 Disease Relevance 0.38 Pain Relevance 0.10
The expression of heat shock protein 25 (Hsp 25) was investigated in the rat temporomandibular joint by immunocytochemistry combined with confocal and electron microscopy.
Spec (investigated) Gene_expression (expression) of Hsp 25 in temporomandibular joint associated with snapping jaw and shock
9) Confidence 0.78 Published 1999 Journal Arch. Histol. Cytol. Section Abstract Doc Link 10678577 Disease Relevance 0.35 Pain Relevance 0.17
One series of our research has shown an intense expression of immunoreaction for heat shock protein 25 (Hsp25) in various cellular elements in the rat temporomandibular joint (TMJ).
Gene_expression (expression) of Hsp25 in TMJ associated with snapping jaw and shock
10) Confidence 0.75 Published 2005 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 15791578 Disease Relevance 0.60 Pain Relevance 0.34
To explore the mechanisms of the elimination of motor neurons, we investigated the expression of two molecules--neuronal nitric oxide synthase (nNOS) as a cytotoxity marker and a 27-kD heat shock protein (HSP27) as a cytoprotection marker--in rat spinal motor neurons after ventral root avulsion, using immunofluorescent labeling technique for confocal laser microscopy.
Spec (investigated) Gene_expression (expression) of HSP27 in motor neurons associated with shock and neuronal nitric oxide synthase
11) Confidence 0.74 Published 2003 Journal Arch. Histol. Cytol. Section Abstract Doc Link 12703557 Disease Relevance 0.17 Pain Relevance 0.05
Hsp27 mRNA expression was significantly elevated (P <0.05) on days 17 to 22 of gestation.
Gene_expression (expression) of Hsp27
12) Confidence 0.68 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.34 Pain Relevance 0.08
The intrinsic growth state of DRG neurons is increased, and Hsp27 is more highly expressed in transgenic mice that over-express ATF-3 [49].
Gene_expression (expressed) of Hsp27 in DRG associated with targeted disruption and dorsal root ganglion
13) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.90 Pain Relevance 0.20
To confirm that the observed changes in gene expression in the transection model are an accurate portrayal of the TPS neuronal response to contusion injury, the expression of 8 different proteins (Gap43, Hspb1, Gfra1, Ret, Casp3, Ntrk1, Ntrk2, and Ntrk3) were examined immunofluorescently in DTMR retrogradely labeled TPS neurons following a moderate spinal contusion injury (NYU Impactor; 25 mm, 10 g weight drop).
Gene_expression (expression) of Hspb1 in neuronal associated with injury and contusions
14) Confidence 0.55 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.87 Pain Relevance 0
There were no effects of pyrethroid exposure on mRNA expression for heat shock 27 kDa protein (Hsp27), brain derived neurotrophic factor (BDNF) or Ras association (RalGAS/AF-6) domain family 6 (Rassf5) (data not shown).
Gene_expression (expression) of Hsp27 in brain associated with shock and bdmf
15) Confidence 0.54 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.17 Pain Relevance 0.14
There were no effects of pyrethroid exposure on mRNA expression for heat shock 27 kDa protein (Hsp27), brain derived neurotrophic factor (BDNF) or Ras association (RalGAS/AF-6) domain family 6 (Rassf5) (data not shown).
Gene_expression (expression) of heat shock 27 kDa protein in brain associated with shock and bdmf
16) Confidence 0.54 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.17 Pain Relevance 0.14
Hsp27 is a downstream product of the dimerisation of ATF-3 and c-Jun, another transcription factor usually up-regulated after axotomy [53] that was not examined in the current study. c-Jun has been associated with apoptosis, neuronal survival, as well as regeneration [53].
Gene_expression (product) of Hsp27 in neuronal associated with apoptosis
17) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.06 Pain Relevance 0.22
In the few genes that were up-regulated (Actb, Atf3, Frs2, Hspb1, Nrap, Stat1) post-axotomy, the expression for all but one was down-regulated by 2-weeks post-injury.
Gene_expression (expression) of Hspb1 associated with injury
18) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC3001741 Disease Relevance 0.83 Pain Relevance 0.09
The expression of Hsp27 inhibits JNK-mediated apoptosis in superior cervical ganglion neurons and adult DRGs [56,57].
Gene_expression (expression) of Hsp27 in neurons associated with ganglion cysts and apoptosis
19) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.67 Pain Relevance 0.11
The active mechanism of bicyclol might be anti-apoptosis of hepatocytes through multiple signaling pathways mainly inducing the expressions of hepatic heat shock proteins (HSP27 and HSP70), molecular chaperons.
Gene_expression (expressions) of HSP27 in hepatocytes associated with shock and apoptosis
20) Confidence 0.29 Published 2009 Journal Medicinal chemistry (Sh?riqah (United Arab Emirates)) Section Abstract Doc Link 19149648 Disease Relevance 1.28 Pain Relevance 0.14

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