INT86605

Context Info Confidence 0.75 First Reported 2000 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.81 Pain Relevance 0.90

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)

Anatomy Link Frequency tail 1 Ntsr1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 6 100.00 Chronic pancreatitis 9 97.12 withdrawal 1 95.52 antinociception 1 94.36 Pain 2 81.44 Antinociceptive 1 75.00 Neuropeptide 1 74.56

Disease Link Frequency Relevance Heat Targeted Disruption 5 98.76 Pancreatic Cancer 9 98.48 Pancreatitis 10 97.12 Hypothermia 1 93.68 Pain 1 81.44 Schizophrenia 1 76.60 Cancer 6 66.32 Nociception 1 63.68 Carcinoma 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In WT mice, both NTR1 agonists decreased core body temperature (active doses in mg/kg, i.p., for NT-2 and NT69L, respectively: 1 and 3), increased tail withdrawal latencies (1 and 3), produced decreased spontaneous climbing (0.1, 0.3, 1 and 1, 3, 10) and reversed apomorphine-induced climbing (0.3, 1 and 1, 3).

Localization (decreased) of NTR1 in tail associated with agonist and withdrawal

1) Confidence 0.75 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19223157 Disease Relevance 0.73 Pain Relevance 0.49

Expression and localization of NTR-1 mRNA was investigated by Northern blot analysis and in situ hybridization.

Localization (localization) of NTR-1 mRNA

2) Confidence 0.63 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10690540 Disease Relevance 1.08 Pain Relevance 0.41

General Comments

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