INT86649

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.85
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN10A) transmembrane transport (SCN10A)
Anatomy Link Frequency
limb 1
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 1 98.66 Very High Very High Very High
Hyperalgesia 1 98.38 Very High Very High Very High
mu opioid receptor 8 95.64 Very High Very High Very High
Spinal cord 2 81.60 Quite High
Inflammation 1 79.92 Quite High
sodium channel 3 79.48 Quite High
Demyelination 1 78.80 Quite High
Spontaneous pain 1 77.44 Quite High
Pain 4 75.00 Quite High
Congenital analgesia 1 74.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 98.66 Very High Very High Very High
Hyperalgesia 1 98.38 Very High Very High Very High
Neuroma 2 97.28 Very High Very High Very High
Infection 5 97.16 Very High Very High Very High
Repression 2 95.20 Very High Very High Very High
Nervous System Injury 1 87.20 High High
Injury 3 82.44 Quite High
INFLAMMATION 1 79.92 Quite High
Demyelinating Disease 1 78.80 Quite High
Pain 4 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve terminals in distal limb neuromas and skin from patients with chronic local hyperalgesia and allodynia all showed marked increases of SNS/PN3-immunoreactive fibers, but little or no NaN/SNS2-immunoreactivity, suggesting that the former may be related to the persistent hypersensitive state.
SNS Binding (little) of in limb associated with hyperalgesia, allodynia and neuroma
1) Confidence 0.36 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 1.11 Pain Relevance 0.71
Transfection with Sp1-expressing vector (PN3-Sp1) was also able to enhance the activity of the promoter in SIVmac239-infected cells.
PN3 Binding (Transfection) of
2) Confidence 0.36 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.74 Pain Relevance 0.39

General Comments

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