INT8667

Context Info Confidence 0.73 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 22 Total Number 22 Disease Relevance 22.74 Pain Relevance 1.25

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)

Anatomy Link Frequency liver 2 bile 2 blood 1 endothelial cell 1 platelet 1 HSD11B1 (Homo sapiens)

Pain Link Frequency Relevance Heat Bile 141 100.00 Bioavailability 12 100.00 Inflammation 76 99.12 Pain 31 94.16 transdermal 6 81.84 Angina 20 75.00 fibrosis 99 73.44 alcohol 30 57.44 Inflammatory response 6 53.96 Potency 7 53.68

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 1308 100.00 Heart Disease 16 100.00 Apoptosis 5 100.00 Metabolic Disorder 3 99.90 Obesity 84 99.84 Acute Coronary Syndrome 41 99.74 Diabetes Mellitus 173 99.52 Coronary Artery Disease 603 99.44 INFLAMMATION 85 99.12 Thrombosis 11 98.84

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Before and after treatment, history, blood pressure, and biochemical values were recorded [blood: Na, K, Ca, creatinine, uric acid, triglycerides, cholesterol, HDL cholesterol, antidiuretic hormone (ADH), and aldosterone; urine: Na, K, Ca, creatinine, ADH, aldosterone, and percentage fraction of Na, K, and Ca excreted].

Localization (excreted) of HDL in urine associated with disorder of lipid metabolism

1) Confidence 0.73 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1377308 Disease Relevance 0.41 Pain Relevance 0

The only factors that were significantly related to ACS case status were HDL-C (OR?

Localization (were) of HDL associated with acute coronary syndrome and disorder of lipid metabolism

2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.46 Pain Relevance 0

Finally, in a pilot study of colesevelam HCl 3.75 g/day administered to 65 men and women with T2DM on oral anti-diabetes drugs (OAD), LDL-C was decreased by 11.7%, HDL-C was not significantly changed, and TG were increased by 7.8% (which was not statistically significant).

Localization (decreased) of HDL associated with diabetes mellitus and disorder of lipid metabolism

3) Confidence 0.73 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.85 Pain Relevance 0.06

Correlation between SRH (3 groups) and HDL-C (the dependents) and various independent factors

Localization (Correlation) of HDL associated with disorder of lipid metabolism

4) Confidence 0.73 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC2096714 Disease Relevance 1.33 Pain Relevance 0.10

In the current study there were significant increases seen for both LDL and total cholesterol in both sexes and in both groups after six months of training, yet the ratio of LDL/HDL was not altered.

Localization (ratio) of HDL associated with disorder of lipid metabolism

5) Confidence 0.73 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.58 Pain Relevance 0

The HDL-C increase produced by fibrates is due not only to the reduction in triglycerides, but also secondary to stimulation of PPAR-?

Localization (secondary) of HDL associated with disorder of lipid metabolism

6) Confidence 0.73 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.67 Pain Relevance 0

HDL and LDL cholesterol were measured by autoanalyzer Kone (Thermo, Vantaa, Finland).

Localization (measured) of HDL associated with disorder of lipid metabolism

7) Confidence 0.73 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 0.89 Pain Relevance 0.16

Female patients had higher HDL cholesterol and lower triglyceride levels than male patients, but higher platelet counts and signs of enhanced platelet activity (beta-thromboglobulin excretion).

Localization (excretion) of HDL in platelet

8) Confidence 0.73 Published 1997 Journal J. Intern. Med. Section Body Doc Link 9042095 Disease Relevance 0.07 Pain Relevance 0

HDL cholesterol concentrations decreased only slightly and haemoglobin increased significantly in the nandrolone decanoate group.

Localization (decreased) of HDL associated with disorder of lipid metabolism

9) Confidence 0.73 Published 1993 Journal Maturitas Section Abstract Doc Link 8133796 Disease Relevance 0.50 Pain Relevance 0.17

In the HDL fraction HDL2 decreased insignificantly but HDL3 cholesterol increased by 12%, p less than 0.05.

Localization (decreased) of HDL associated with disorder of lipid metabolism

10) Confidence 0.73 Published 1984 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 6587755 Disease Relevance 0.56 Pain Relevance 0.15

It indicated that HDL metabolic disorders and HDL maturation are blocked in the TG ?

Localization (maturation) of HDL associated with metabolic disorder and disorder of lipid metabolism

11) Confidence 0.51 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.93 Pain Relevance 0

The relationship between testosterone and HDL is confounded by the fact that both HDL and testosterone are inversely related to BMI.

Localization (related) of HDL associated with obesity and disorder of lipid metabolism

12) Confidence 0.28 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.55 Pain Relevance 0.04

Elevated HDL secondary to CETP deficiency may not then be entirely atheroprotective.

Localization (secondary) of HDL associated with disorder of lipid metabolism

13) Confidence 0.24 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 1.04 Pain Relevance 0

As the name suggests, the reverse cholesterol transport process involves the transport of HDL-C from peripheral tissues and transfer to VLDL-C and LDL-C back to liver for secretion in the bile.9 HDL-C is also believed to have anti-inflammatory, anti-oxidative, platelet anti-aggregatory, anticoagulation, and profibrolytic effects,13 which can help reduce damage mediated by high levels of LDL-C.

Localization (secretion) of HDL in bile associated with bile, inflammation and disorder of lipid metabolism

14) Confidence 0.24 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.33 Pain Relevance 0.12

This process is mediated by HDL-C and involves the transfer of cholesterol from macrophages/foam cells present in peripheral tissues through the blood stream to the liver, with subsequent metabolism of cholesterol and secretion into the bile.9 Other potential mechanisms include maintenance of endothelial integrity through increased nitric oxide (a vasodilator) bioavailability, promotion of endothelial cell proliferation and migration, and prevention of endothelial cell apoptosis.25 Moreover, HDL-C has been shown to inhibit thrombosis, oxidation,25 and inflammation,26 all of which can contribute to atherosclerosis and CHD.

Localization (secretion) of HDL in endothelial cell associated with bile, coronary artery disease, increased venous pressure under development, apoptosis, thrombosis, bioavailability, inflammation and disorder of lipid metabolism

15) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.74 Pain Relevance 0.15

HDL as a risk factor for heart disease

Localization (disease) of HDL in heart associated with heart disease and disorder of lipid metabolism

16) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.79 Pain Relevance 0

Systematic review of HDL-C and CH29

Localization (review) of HDL associated with disorder of lipid metabolism

17) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.44 Pain Relevance 0

As the name suggests, the reverse cholesterol transport process involves the transport of HDL-C from peripheral tissues and transfer to VLDL-C and LDL-C back to liver for secretion in the bile.9 HDL-C is also believed to have anti-inflammatory, anti-oxidative, platelet anti-aggregatory, anticoagulation, and profibrolytic effects,13 which can help reduce damage mediated by high levels of LDL-C.

Localization (secretion) of HDL in bile associated with bile, inflammation and disorder of lipid metabolism

18) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.37 Pain Relevance 0.13

As shown by de Beer and colleagues, sPLA2-IIA dependent hydrolysis of HDL results in a more efficient scavenger receptor class B type I cholesteryl ester uptake, leading to an accelerated HDL catabolism in the kidney during inflammatory states (deBeer et al 2000).

Localization (catabolism) of HDL in kidney associated with inflammation and disorder of lipid metabolism

19) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.01 Pain Relevance 0.16

Apolipoprotein A1 is the major protein component of the high-density lipoprotein (HDL) particles, which promotes cholesterol efflux from tissues to the liver for excretion.

Localization (excretion) of HDL in liver associated with disorder of lipid metabolism

20) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012070 Disease Relevance 1.53 Pain Relevance 0

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