INT86769

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.60
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
DRG 3
mammary gland 2
sensory neurons 2
retina 2
Mouse 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 79 100.00 Very High Very High Very High
Neuropathic pain 10 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Kappa opioid receptor 9 100.00 Very High Very High Very High
nociceptor 50 99.98 Very High Very High Very High
Dopamine 2 99.48 Very High Very High Very High
Cannabinoid receptor 4 99.44 Very High Very High Very High
Spinal cord 25 98.64 Very High Very High Very High
orphanin 3 97.04 Very High Very High Very High
Hippocampus 1 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 14 100.00 Very High Very High Very High
Targeted Disruption 88 99.98 Very High Very High Very High
Apoptosis 21 98.60 Very High Very High Very High
Breast Cancer 54 97.84 Very High Very High Very High
Anxiety Disorder 1 97.28 Very High Very High Very High
Metastasis 57 93.76 High High
Syndrome 4 90.32 High High
Death 9 89.04 High High
Coma 2 88.64 High High
Pain 14 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What aspects of learning EphA receptors mediate have not been studied?
Positive_regulation (mediate) of Gene_expression (aspects) of receptors
1) Confidence 0.25 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10701657 Disease Relevance 0.39 Pain Relevance 0.25
Mouse CAPER (HCC1.3) was reported to enhance activation of ER?
Positive_regulation (activation) of Gene_expression (enhance) of CAPER in Mouse
2) Confidence 0.17 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
On the basis of numerous studies that have described interactions between the dopaminergic and opioidergic systems, we have investigated whether genetic deletion of dopamine D2 receptors (D2R) might influence the expression of central opioid receptors.
Spec (might) Positive_regulation (influence) of Gene_expression (expression) of receptors associated with dopamine and opioid receptor
3) Confidence 0.11 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.09 Pain Relevance 0.42
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of receptors in DRG associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
4) Confidence 0.06 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.60 Pain Relevance 0.76
The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.
Positive_regulation (generated) of Gene_expression (occur) of receptors
5) Confidence 0.03 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.83 Pain Relevance 0.09
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Positive_regulation (induced) of in spinal cord Gene_expression (expression) of receptors in DRG associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
6) Confidence 0.02 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.60 Pain Relevance 0.76
A large body of evidence shows that nociceptors depend for their survival during development on NGF signaling through TrkA receptors specifically expressed on these cells [4-6].
Positive_regulation (depend) of Gene_expression (expressed) of receptors in nociceptors associated with nociceptor
7) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.18 Pain Relevance 0.61
Early sensory neurons express multiple Trk receptors, and depend on the activity of Runx transcription factors to refine this non-specific pattern into mutually exclusive TrkA, TrkB and TrkC expression.
Positive_regulation (depend) of Gene_expression (express) of receptors in sensory neurons
8) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.36 Pain Relevance 0.12
Stronger expression of NMDA receptors with NR2C/D subunits by inhibitory interneurons compared to excitatory interneurons may provide a mechanism to selectively increase activity of inhibitory neurons during intense excitatory drive that can provide inhibitory feedback.



Positive_regulation (Stronger) of Gene_expression (expression) of receptors in interneurons associated with nmda receptor
9) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2879240 Disease Relevance 0.07 Pain Relevance 0.44
The synthesis of retinoic acid is regulated in a focus-dependent manner in the choroid and the retina [52-54] and the expression of retinal retinoic acid receptors was found to be increased under form-deprivation conditions [55].
Positive_regulation (increased) of Gene_expression (expression) of receptors in retina
10) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.24 Pain Relevance 0.04
A recent study showed that transgenic overexpression of autotaxin or LPA1-3 receptors in the mouse mammary gland is sufficient to initiate breast cancers in mice, demonstrating that activation of the autotaxin/LPA track induces carcinogenesis [25].
Positive_regulation (overexpression) of Gene_expression (overexpression) of receptors in mammary gland associated with targeted disruption and breast cancer
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.24 Pain Relevance 0
Permanent cell lines (HEK 293, NG 108-15) were transfected to express either green fluorescent kappa-receptors or to coexpress the tagged receptor and a specific GRK-DsRed construct.
Positive_regulation (transfected) of Gene_expression (express) of receptors
12) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.32

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