INT86909

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 12.65
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
Anatomy Link Frequency
MLH1 2
GALT 1
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 6 100.00 Very High Very High Very High
metalloproteinase 7 99.88 Very High Very High Very High
cINOD 7 97.36 Very High Very High Very High
endometriosis 8 91.08 High High
aspirin 4 87.52 High High
Opioid 1 87.36 High High
Inflammation 13 85.12 High High
chemokine 1 83.08 Quite High
Piles 3 75.00 Quite High
Pain 3 67.16 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 100.00 Very High Very High Very High
Microsatellite Instability 158 99.76 Very High Very High Very High
Cancer 386 99.74 Very High Very High Very High
Endometrial Cancer 232 99.52 Very High Very High Very High
Colon Cancer 118 99.40 Very High Very High Very High
Apoptosis 63 96.04 Very High Very High Very High
Endometroid Carcinoma 33 95.12 Very High Very High Very High
Fistula 3 91.32 High High
Endometriosis (extended) 12 91.08 High High
Chromosomal Instability 2 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of hMSH2, one of the most commonly hMMR genes, is a described alternative pathway in cancer development and progression.
Negative_regulation (Inactivation) of hMSH2 associated with cancer
1) Confidence 0.41 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.55 Pain Relevance 0.11
MSH2 DNA mismatch repair protein MSH2
Negative_regulation (repair) of MSH2
2) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.68 Pain Relevance 0.40
The tumor specimens showed no MLH1 expression but did show normal MSH2 expression. p53 was not expressed.
Negative_regulation (p53) of MSH2 in MLH1 associated with cancer
3) Confidence 0.35 Published 2007 Journal J Nippon Med Sch Section Abstract Doc Link 17878704 Disease Relevance 2.67 Pain Relevance 0.10
Unlike HNPCC associated colorectal carcinoma, which appears to frequently have MLH1 and MSH2 mutations, endometrial carcinomas have a higher probability of MSH2 and MSH6 mutations [13, 25].
Negative_regulation (have) of MSH2 in MLH1 associated with colon cancer and endometrial cancer
4) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.67 Pain Relevance 0
The mechanism for the inactivation of MSH2 is still not clear, as promoter methylation and mutations are rare.
Negative_regulation (inactivation) of MSH2
5) Confidence 0.25 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.11 Pain Relevance 0
MSI frequency in cells deficient of MMR genes (hMSH2, hMLH1, hMSH6) was markedly reduced after long-term (> 10 weeks) NSAID treatment.
Negative_regulation (deficient) of hMSH2 associated with cinod and microsatellite instability
6) Confidence 0.10 Published 1999 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 10714217 Disease Relevance 1.32 Pain Relevance 0.53
Loss of heterozygosity in adenomyosis on hMSH2, hMLH1, p16Ink4 and GALT loci.
Negative_regulation (Loss) of hMSH2 in GALT associated with dismenorea
7) Confidence 0.04 Published 2000 Journal Int. J. Mol. Med. Section Title Doc Link 11078826 Disease Relevance 0.74 Pain Relevance 0.56
Because we noted fluctuation in hMSH2 levels throughout the treatment of several patients, it is possible that hMSH2 downregulation occurs at the post-transcriptional level and could be related to the use of chemotherapy based on alkylating agents.
Negative_regulation (downregulation) of hMSH2
8) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064099 Disease Relevance 1.09 Pain Relevance 0
While all 9 tumors with hMLH1, hMSH2, or hPMS2 losses were MSI-H, only 2/5 of the CRCs with isolated losses of hMSH6 were MSI-H; in both cases, just 3/5 markers were mutated and in the other three, none were mutated.
Negative_regulation (losses) of hMSH2 associated with cancer and microsatellite instability
9) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.83 Pain Relevance 0

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