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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 68
Total Number 68
Disease Relevance 46.98
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
T cells 7
colon 4
brain 3
macrophage 2
GL1 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 12 99.64 Very High Very High Very High
cOX1 1 99.64 Very High Very High Very High
cINOD 66 99.54 Very High Very High Very High
cytokine 244 99.28 Very High Very High Very High
Inflammation 580 97.40 Very High Very High Very High
Sicca syndrome 21 96.56 Very High Very High Very High
tolerance 48 96.04 Very High Very High Very High
addiction 15 95.92 Very High Very High Very High
chemokine 19 92.84 High High
ischemia 68 92.80 High High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 2036 100.00 Very High Very High Very High
Cancer 1697 100.00 Very High Very High Very High
Adenoma 417 100.00 Very High Very High Very High
Targeted Disruption 272 100.00 Very High Very High Very High
Adenomatous Polyps 93 100.00 Very High Very High Very High
Polyps 577 99.78 Very High Very High Very High
Infection 297 99.66 Very High Very High Very High
Colon Cancer 387 99.60 Very High Very High Very High
Apoptosis 261 99.48 Very High Very High Very High
Intestinal Cancer 25 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second significant feature of the APC gene product is its interaction with the adherins junction proteins called catenins, to date at least three proteins have been identified that interact with APC, these being ?
Gene_expression (product) of APC associated with familial adenomatous polyposis
1) Confidence 0.67 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.06 Pain Relevance 0
We investigated dietary arginine-induced intestinal tumorigenesis and NSAID-inhibitory effects in Apc(Min/+) mice differentially expressing nitric oxide synthase-2 (Nos2).
Gene_expression (expressing) of Apc associated with cinod
2) Confidence 0.66 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.67 Pain Relevance 0.28
We investigated dietary arginine-induced intestinal tumorigenesis and NSAID-inhibitory effects in Apc(Min/+) mice differentially expressing nitric oxide synthase-2 (Nos2).
Gene_expression (expressing) of Min associated with cinod
3) Confidence 0.65 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.67 Pain Relevance 0.28
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.
Gene_expression (expression) of Min associated with adenoma
4) Confidence 0.65 Published 2008 Journal Carcinogenesis Section Title Doc Link 18499699 Disease Relevance 0.82 Pain Relevance 0.20
The Apc(Min/+) mouse, which expresses a mutant homolog of the adenomatous polyposis coli gene, is a model of FAP in humans.
Gene_expression (expresses) of adenomatous polyposis coli associated with familial adenomatous polyposis
5) Confidence 0.59 Published 2008 Journal Nutr Cancer Section Abstract Doc Link 19003578 Disease Relevance 0.95 Pain Relevance 0.16
We estimate that a mutation in the APC gene will be more severe then mutation in the MUTYH gene, as the APC gene is part of the Wnt pathway and can influence several cellular functions such as proliferation, differentiation, apoptosis, adhesion, migration, and chromosomal segregation.
Gene_expression (part) of APC gene associated with familial adenomatous polyposis, apoptosis and adhesions
6) Confidence 0.58 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.90 Pain Relevance 0
Inhaled APC prevents deterioration of lung function in response to alveolar distention
Neg (prevents) Gene_expression (prevents) of APC in lung
7) Confidence 0.54 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0 Pain Relevance 0
Quiescent cultures were pretreated or not with APC (10 ?
Neg (not) Gene_expression (pretreated) of APC
8) Confidence 0.54 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0 Pain Relevance 0.03
L NS (HVt-APC group, n = 6), or 30 ?
Gene_expression (group) of HVt-APC
9) Confidence 0.54 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.33 Pain Relevance 0.05
Disturbed APC structure and functions in brief
Gene_expression (structure) of APC associated with familial adenomatous polyposis
10) Confidence 0.51 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.34 Pain Relevance 0
What to test for first: APC or MUTYH mutation?
Gene_expression (mutation) of APC associated with familial adenomatous polyposis
11) Confidence 0.51 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.66 Pain Relevance 0
APC disturbed structure and function in FAP in humans and animal models
Gene_expression (function) of APC associated with familial adenomatous polyposis
12) Confidence 0.51 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.83 Pain Relevance 0
When the family's specific APC mutation is identified, genetic testing of all first degree relatives should be performed even when the parents test negative [28,35,39].
Gene_expression (mutation) of APC associated with familial adenomatous polyposis
13) Confidence 0.51 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.47 Pain Relevance 0
Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice.
Gene_expression (regression) of APC associated with cox1 and adenomatous polyps
14) Confidence 0.50 Published 2003 Journal J Invest Surg Section Title Doc Link 12746190 Disease Relevance 1.21 Pain Relevance 0.29
We used unpaired t test with Welsh's correction analysis to correlate the sets of values of intensity per voxel in the particles of the APC?
Gene_expression (particles) of APC associated with familial adenomatous polyposis
15) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.82 Pain Relevance 0.10
0.004540 for the APC?
Gene_expression (0.004540) of APC associated with familial adenomatous polyposis
16) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.43 Pain Relevance 0
In agreement with this conclusion, we found no significant difference in the “specific intensity” (intensity per µm3) of the particles found in APC?
Gene_expression (found) of APC associated with familial adenomatous polyposis
17) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.45 Pain Relevance 0
The agency has requested further clinical data to support the efficacy claims in the Biologics License Application, as well as further information on the chemistry, manufacture and controls for APC8015 production.
Gene_expression (production) of APC8015
18) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503669 Disease Relevance 0.30 Pain Relevance 0
To reveal the cellular source of cathepsin activity, APC?
Gene_expression (source) of APC associated with familial adenomatous polyposis
19) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.47 Pain Relevance 0
Effects of chronic Zangrado in ApcMin/+mice
Gene_expression (+mice) of ApcMin
20) Confidence 0.43 Published 2008 Journal J Transl Med Section Body Doc Link PMC2254379 Disease Relevance 0.96 Pain Relevance 0.22

General Comments

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