INT87230

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Context Info
Confidence 0.80
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.51
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ECE1) peptidase activity (ECE1) plasma membrane (ECE1)
Anatomy Link Frequency
placenta 2
vesicles 1
ECE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 100.00 Very High Very High Very High
Kinase C 4 81.52 Quite High
Dismenorea 2 75.20 Quite High
Catecholamine 2 69.12 Quite High
cytokine 4 64.40 Quite High
Angina 1 54.48 Quite High
antagonist 82 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 99.20 Very High Very High Very High
Increased Venous Pressure Under Development 23 98.16 Very High Very High Very High
Eclampsia 2 94.60 High High
Targeted Disruption 5 85.48 High High
Coronary Vasospasm 3 85.40 High High
Dysmenorrhea 2 75.20 Quite High
Stress 6 72.80 Quite High
Hypoxia 2 61.60 Quite High
Natriuresis 4 45.04 Quite Low
Pulmonary Hypertension 130 30.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of ECE-1 corresponds with the previously reported distribution of ET-1 in the human placenta and is in accordance with the function of this enzyme in regulating vascular tone through synthesis of ET-1.
Localization (localization) of ECE-1 in placenta
1) Confidence 0.80 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.15 Pain Relevance 0.08
Immunohistochemical localization of ECE-1 in the human placenta.
Localization (localization) of ECE-1 in placenta
2) Confidence 0.80 Published 2000 Journal Placenta Section Title Doc Link 10736246 Disease Relevance 0.15 Pain Relevance 0.05
By contrast, ECE-1b is located intracellularly close to the trans-Golgi networks.
Localization (located) of ECE-1b
3) Confidence 0.27 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.27 Pain Relevance 0.11
ECE-1a is abundant in endothelial cells and resides within intracellular secretory vesicles and is constitutively transported to the cell surface (Russell and Davenport 1999).
Localization (transported) of ECE-1a in vesicles
4) Confidence 0.27 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.26 Pain Relevance 0.10
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Localization (activation) of endothelin-converting enzyme associated with serotonin
5) Confidence 0.13 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.69 Pain Relevance 0.19
Similarly, it appears that ECE-1 and ECE-2 arose from a common ancestral gene after the divergence of the vertebrates and urochordates.
Localization (arose) of ECE-1
6) Confidence 0.10 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0

General Comments

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