INT87231

From wiki-pain
Revision as of 13:21, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.47
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ECE1) peptidase activity (ECE1) plasma membrane (ECE1)
Anatomy Link Frequency
endothelial cells 2
smooth muscle 1
vesicles 1
ECE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 3 99.92 Very High Very High Very High
Kinase C 2 66.48 Quite High
Catecholamine 1 54.08 Quite High
cytokine 2 49.36 Quite Low
antagonist 41 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 3 99.92 Very High Very High Very High
Eclampsia 3 86.88 High High
Targeted Disruption 1 85.48 High High
Stress 3 57.76 Quite High
Hypoxia 1 46.56 Quite Low
Pulmonary Hypertension 65 30.52 Quite Low
Natriuresis 2 30.00 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By immunohistochemical analysis and immunofluorescence, endothelin-converting enzyme-1 (ECE-1), the enzyme that synthesizes ET-1, is localized to five distinct cell populations in the human placenta: (1) the endothelial cells lining the maternal basal plate blood vessels, (2) the intermediate trophoblasts, (3) the endothelial cells lining the chorionic villous blood vessels, (4) the chorionic villous stromal cells and (5) the chorionic villous trophoblasts.
endothelin-converting enzyme-1 Binding (localized) of in endothelial cells
1) Confidence 0.37 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.09 Pain Relevance 0
By immunohistochemical analysis and immunofluorescence, endothelin-converting enzyme-1 (ECE-1), the enzyme that synthesizes ET-1, is localized to five distinct cell populations in the human placenta: (1) the endothelial cells lining the maternal basal plate blood vessels, (2) the intermediate trophoblasts, (3) the endothelial cells lining the chorionic villous blood vessels, (4) the chorionic villous stromal cells and (5) the chorionic villous trophoblasts.
ECE-1 Binding (localized) of in endothelial cells
2) Confidence 0.37 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.09 Pain Relevance 0
ECE-1 may serve as a target for prognosis and therapy in states of pathologically altered vascular tone and/or altered myometrial smooth muscle tone in gestation.
ECE-1 Binding (target) of in smooth muscle
3) Confidence 0.36 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.16 Pain Relevance 0.10
ECE-1a is abundant in endothelial cells and resides within intracellular secretory vesicles and is constitutively transported to the cell surface (Russell and Davenport 1999).
ECE-1a Binding (abundant) of in vesicles
4) Confidence 0.14 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.14 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox