INT87304

Context Info Confidence 0.60 First Reported 2000 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.70 Pain Relevance 0.96

extracellular space (Cxcl1) extracellular region (Cxcl1)

Anatomy Link Frequency pancreas 1 Cxcl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 22 99.26 Chronic pancreatitis 4 92.60 cva 1 89.28 Inflammation 54 86.56 fibrosis 1 80.32 Bile 7 69.44 cINOD 3 57.40 ischemia 1 55.00 antagonist 1 16.72 substance P 6 5.00

Disease Link Frequency Relevance Heat Pancreatitis 5 100.00 Acid Reflux 18 98.70 Adhesions 6 91.64 Hemorrhage 1 89.28 Edema 1 88.32 INFLAMMATION 49 86.56 Fibrosis 1 80.32 Esophageal Disease 20 75.04 Gastroesophageal Reflux Disease 45 60.00 Cv Unclassified Under Development 1 55.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore mRNA expression of each CINC was inhibited by dexamethasone in a dose-dependent manner.

Transcription (expression) of CINC

1) Confidence 0.60 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0

Cytokine-induced neutrophil chemoattractant (CINC), interleukin (IL) -6, pancreatitis-associated protein (PAP), and p8 mRNAs in the pancreas were detected with semiquantitative reverse transcription-polymerase chain reaction (RT-PCR).

Transcription (detected) of CINC in pancreas associated with pancreatitis and cytokine

2) Confidence 0.24 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11837714 Disease Relevance 0.76 Pain Relevance 0.52

We previously reported that in a rat model of mixed reflux esophagitis, intraduodenal rebamipide significantly inhibited the increased expression of mRNA and protein for CINC-1 and TNF-?

Transcription (expression) of CINC-1 associated with acid reflux

3) Confidence 0.16 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.86 Pain Relevance 0.44

General Comments

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