INT87360

Context Info Confidence 0.47 First Reported 2000 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.71 Pain Relevance 2.38

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1) nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)

ABCC1 (Homo sapiens)

Pain Link Frequency Relevance Heat cannabis 245 100.00 methotrexate 22 100.00 cINOD 13 100.00 diclofenac 5 94.52 Inflammation 2 92.88 Potency 5 65.28 Nicotine 23 46.96 agonist 18 17.60 Glutamate 29 5.00 alcohol 20 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 7 100.00 Disease 7 92.36 Alzheimer's Dementia 4 92.12 Psychosis 61 89.40 Amyloidosis 2 81.88 Coronary Heart Disease 1 80.60 Familial Amyloidotic Polyneuropathy 1 79.28 Schizophrenia 31 70.16 Targeted Disruption 14 5.00 Mental Disorders 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport.

MRP Binding (Interaction) of associated with inflammation, cinod and methotrexate

1) Confidence 0.47 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17005917 Disease Relevance 0.38 Pain Relevance 0.92

Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport.

multidrug resistance protein Binding (Interaction) of associated with inflammation, cinod and methotrexate

2) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17005917 Disease Relevance 0.38 Pain Relevance 0.92

However, there are no data regarding the contribution of rat Mdr1 to diazepam pharmacokinetics or of rat Mrp1 and human MRP2 in the case of grepafloxacin.

Mrp1 Neg (no) Binding (contribution) of

3) Confidence 0.15 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2542356 Disease Relevance 0 Pain Relevance 0.03

This suggests that ethanol produces mixture interactions with GalA-MRP resulting in a decrease in the salt perception.

MRP Binding (interactions) of

4) Confidence 0.14 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0

Crystal structures of the protein-drug complexes have been determined to allow detailed analyses of the protein-drug interactions that stabilize the native tetrameric conformation of TTR and inhibit the formation of amyloidogenic TTR.

protein-drug Binding (interactions) of

5) Confidence 0.02 Published 2000 Journal Nat. Struct. Biol. Section Abstract Doc Link 10742177 Disease Relevance 0.65 Pain Relevance 0.14

Self reported LTC use was strongly associated with being diagnosed with SSD.

LTC Binding (associated) of associated with cannabis

6) Confidence 0.00 Published 2010 Journal Subst Abuse Treat Prev Policy Section Abstract Doc Link PMC2910013 Disease Relevance 0.30 Pain Relevance 0.37

General Comments

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