INT87406

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 11.37
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTP1) small molecule metabolic process (GSTP1) plasma membrane (GSTP1)
nucleus (GSTP1) intracellular (GSTP1) protein complex (GSTP1)
Anatomy Link Frequency
superior 1
lung 1
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 9 93.68 High High
qutenza 1 88.76 High High
Inflammation 76 74.16 Quite High
dorsal root ganglion 2 73.52 Quite High
induced neuropathy 1 58.36 Quite High
Bioavailability 16 39.28 Quite Low
alcohol 10 23.64 Low Low
COX-2 inhibitor 5 8.40 Low Low
antagonist 47 5.00 Very Low Very Low Very Low
metalloproteinase 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 27 99.60 Very High Very High Very High
Obesity 38 99.52 Very High Very High Very High
Cancer 705 99.36 Very High Very High Very High
Myocardial Infarction 8 99.04 Very High Very High Very High
Stress 113 98.92 Very High Very High Very High
Apoptosis 227 98.84 Very High Very High Very High
Leukemia 12 98.64 Very High Very High Very High
Squamous Cell Neoplasms 1 97.80 Very High Very High Very High
Stomach Cancer 30 97.44 Very High Very High Very High
Endometrial Cancer 67 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in another study that measured GSTP1 expression in esophageal tissue among patients receiving chemoradiation, higher expression was associated with poorer survival [23], strengthening the hypothesis that reduced levels of GSTP1 are associated with greater cell kill.
Gene_expression (expression) of GSTP1
1) Confidence 0.77 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.51 Pain Relevance 0
The GSTP1 gene product provides > 90% of the GST family activity in the lung; enhancement of the allergic response by secondhand tobacco smoke was larger in allergen-sensitive individuals with the GSTP1 wild type (Gilliland et al. 2006).
Gene_expression (product) of GSTP1 in lung associated with nicotine addiction and hypersensitivity
2) Confidence 0.73 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.71 Pain Relevance 0
Oxidative stress releases GSTP1 from JNK, which in turn activates the expression of GSTP1 and other genes involved in apoptosis and cytoprotection [39].
Gene_expression (expression) of GSTP1 associated with stress and apoptosis
3) Confidence 0.68 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.87 Pain Relevance 0.10
While another study showed patients possessing the GSTP1-105 Val/Val genotype showed a significant superior response in gastric cancer (23).
Gene_expression (possessing) of GSTP1 in superior associated with stomach cancer
4) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877230 Disease Relevance 0.53 Pain Relevance 0
In the linear regression analysis after adjustment of age, sex, and BMI, none of the GSTM1 and GSTP1 genotypes showed statistically significant effect on the relation between serum TNF-?
Gene_expression (genotypes) of GSTP1 associated with obesity
5) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.96 Pain Relevance 0.07
Table 3 shows the distribution of NAT2, GSTM1, GSTT1, and GSTP1 genotypes by self-reported chemical-related sensitivity score (?
Gene_expression (distribution) of GSTP1
6) Confidence 0.66 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.18 Pain Relevance 0
DNA was analyzed for deletions in the GSTM1 and T1 genes and for substitutions in EPXH and GSTP1 genes.
Spec (analyzed) Gene_expression (deletions) of GSTP1
7) Confidence 0.65 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744635 Disease Relevance 1.26 Pain Relevance 0.09
Our results demonstrate the ability of selected chemopreventive agents to decrease GSTP1-1 gene expression mechanisms and could thus contribute to reduce the incidence of glutathione related drug resistance in human leukemia.
Gene_expression (expression) of GSTP1-1 associated with leukemia
8) Confidence 0.54 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.39 Pain Relevance 0.09
This corresponds to an earlier observation that GSTP1 expression was downregulated by curcumin in leukaemia cells [63].
Gene_expression (expression) of GSTP1 associated with leukemia
9) Confidence 0.35 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.24 Pain Relevance 0
In the current study, we found that glutathione synthetase, glutathione S-transferase, glutathione S-transferase omega, glutathione transferase P1–1, and peroxiredoxin-2 isoform-a were all expressed at least twofold higher in HCEC cultured from young donors, suggesting that HCEC cultured from older donors have decreased protection against oxidative stress compared to their younger counterparts.
Gene_expression (expressed) of transferase P1 associated with stress
10) Confidence 0.29 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2565687 Disease Relevance 0.48 Pain Relevance 0
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Gene_expression (expressed) of GSTP1 associated with endometrial cancer
11) Confidence 0.26 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.29 Pain Relevance 0
Finally, it was suggested that that cells overexpressing GSTP1-1 could protect neighboring cells from hypericin-dependent PDT by sequestering the photosensitizer.
Gene_expression (overexpressing) of GSTP1-1 associated with cancer
12) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.62 Pain Relevance 0
It was also postulated that over-expression of GSTP1-1 caused a change in the expression of transport proteins, and thus altered the steady-state levels of intracellular hypericin.
Gene_expression (over) of GSTP1-1
13) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.58 Pain Relevance 0
Surprisingly, GSTP1-1 over-expression led to an increase in cellular uptake of hypericin, which suggested that this may result from direct sequestration of hypericn by GSTP1-1.
Gene_expression (over) of GSTP1-1
14) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.53 Pain Relevance 0
It was also postulated that over-expression of GSTP1-1 caused a change in the expression of transport proteins, and thus altered the steady-state levels of intracellular hypericin.
Gene_expression (expression) of GSTP1-1
15) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.58 Pain Relevance 0
Surprisingly, GSTP1-1 over-expression led to an increase in cellular uptake of hypericin, which suggested that this may result from direct sequestration of hypericn by GSTP1-1.
Gene_expression (expression) of GSTP1-1
16) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.53 Pain Relevance 0
Afterward, in 2001 Lin et al. reported that procainamide was able to demethylate and restore GSTP1 gene expression in LNCaP prostatic carcinoma cell line in vitro and in nude mice carrying prostatic carcinoma xenografts [184].
Gene_expression (expression) of GSTP1 gene associated with prostate cancer
17) Confidence 0.05 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.10 Pain Relevance 0

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