INT87436

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 3.95
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
fibroblast 2
precursor cells 1
spinal cord 1
brain 1
astrocytes 1
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 29 100.00 Very High Very High Very High
COX-2 inhibitor 1 99.80 Very High Very High Very High
antidepressant 90 98.20 Very High Very High Very High
Spinal cord 196 97.84 Very High Very High Very High
endometriosis 2 95.36 Very High Very High Very High
rheumatoid arthritis 6 94.08 High High
sSRI 36 85.44 High High
sNRI 4 85.16 High High
Hippocampus 24 80.04 Quite High
Kinase C 1 78.48 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 48 97.84 Very High Very High Very High
Age-related Macular Degeneration 2 97.76 Very High Very High Very High
Diabetic Retinopathy 2 96.24 Very High Very High Very High
Endometriosis (extended) 3 95.36 Very High Very High Very High
Increased Venous Pressure Under Development 2 94.76 High High
Rheumatoid Arthritis 6 94.08 High High
Cancer 89 93.20 High High
Disease 109 92.60 High High
Injury 34 88.72 High High
Neurodegenerative Disease 37 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NS-398, a specific COX-2 inhibitor, did not affect the FGF-2 stimulation on purified osteoclasts but inhibited that on unfractionated bone cells.
Neg (not) Regulation (affect) of FGF-2 in osteoclasts associated with cox-2 inhibitor
1) Confidence 0.45 Published 2000 Journal J. Bone Miner. Res. Section Abstract Doc Link 10750561 Disease Relevance 0.39 Pain Relevance 0.33
The purpose of this study was to examine the effects of cyclooxygenase inhibitors on basic fibroblast growth factor (bFGF)- and vascular endothelial growth factor (VEGF)-mediated ocular neovascularization and permeability.
Spec (examine) Regulation (effects) of bFGF in fibroblast
2) Confidence 0.45 Published 2008 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 18487370 Disease Relevance 0.90 Pain Relevance 0.17
The purpose of this study was to examine the effects of cyclooxygenase inhibitors on basic fibroblast growth factor (bFGF)- and vascular endothelial growth factor (VEGF)-mediated ocular neovascularization and permeability.
Spec (examine) Regulation (effects) of basic fibroblast growth factor in fibroblast
3) Confidence 0.45 Published 2008 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 18487370 Disease Relevance 0.90 Pain Relevance 0.17
These modifications combined the gradient enrichment procedure originally described for rat hippocampal precursor cells with the addition of both EGF and FGF2, the use of B27 as the serum supplement, the control of appropriate plating densities, and the optional use of additional exogenous factors for the trophic support of the cultured cells.
Regulation (control) of FGF2 in precursor cells
4) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
Our findings support these results, where FGF-2 immunoreactivity was found in large amounts, at the first week, after spinal cord injury, and significantly decreased during the second week in SC3.
Regulation (immunoreactivity) of FGF-2 in spinal cord associated with spinal cord
5) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.25 Pain Relevance 0.30
In sham-operated animals, FGF-2 immunoreactivity was extremely light, sparse and occasionally present in the white matter.
Regulation (immunoreactivity) of FGF-2 in white matter
6) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.04
Because astrocytes synthesize FGF-2 (Gomez-Pinilla et al., 1994) and express FGF receptors (FGFRs) -2 and -3 (Reuss et al., 2000), FGF-2 is a major candidate for the autocrine and/or paracrine regulation of astroglial cell differentiation, functions, and transition to a “reactive” phenotype.
Regulation (regulation) of FGF-2 in astrocytes
7) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.07 Pain Relevance 0.10
A strong widespread colocalization was prominent between FGF-2 and GFAP immunoreactivity.


Regulation (immunoreactivity) of FGF-2
8) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
HMEC-1 cells migrated to the reverse side of the filters were removed with trypsin and counted. a FGF-2 (5 ng/ml) was used as a positive control for inducing HMEC-1 migration (open column).
Regulation (control) of FGF-2
9) Confidence 0.23 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0 Pain Relevance 0
Even though these experiments did not show direct evidence that the PTTG1 protein binds to the bFGF promoter, the reporter gene assay showed that there is a direct or indirect role of PTTG1 protein and PBF on bFGF transcriptional regulation.
Regulation (regulation) of bFGF
10) Confidence 0.19 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.48 Pain Relevance 0.04
The underlying mechanisms that mediate the neurogenic effects of antidepressants have not been identified, but there is strong evidence that neurotrophic factors such as fibroblast growth factor-2, insulin-like growth factor-1 (IGF-1) and brain derived neurotrophic factor (BDNF) are important for this effect [4].
Regulation (important) of fibroblast growth factor-2 in brain associated with antidepressant and bdmf
11) Confidence 0.09 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 0.95 Pain Relevance 0.74

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