INT87470

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 24.86
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC1) small molecule metabolic process (SDC1) extracellular region (SDC1)
plasma membrane (SDC1) protein complex (SDC1) lipid metabolic process (SDC1)
Anatomy Link Frequency
plasma cells 2
liver 1
colon 1
epithelial cells 1
bowel 1
SDC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 195 99.84 Very High Very High Very High
Arthritis 132 99.56 Very High Very High Very High
Chronic pancreatitis 27 99.52 Very High Very High Very High
spastic colon 4 99.04 Very High Very High Very High
Crohn's disease 36 99.00 Very High Very High Very High
Multiple sclerosis 80 98.60 Very High Very High Very High
metalloproteinase 82 98.42 Very High Very High Very High
Inflammation 103 96.64 Very High Very High Very High
Central nervous system 31 96.48 Very High Very High Very High
imagery 38 95.00 High High
Disease Link Frequency Relevance Heat
Cancer 208 99.86 Very High Very High Very High
Rheumatoid Arthritis 195 99.84 Very High Very High Very High
Pancreatic Cancer 72 99.84 Very High Very High Very High
Lung Cancer 138 99.66 Very High Very High Very High
Seronegative Spondarthritis 120 99.56 Very High Very High Very High
Necrosis 11 99.56 Very High Very High Very High
Pancreatitis 27 99.52 Very High Very High Very High
Functional Bowel Disorder 4 99.04 Very High Very High Very High
Disease 178 99.00 Very High Very High Very High
Adhesions 36 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic cancer cell lines expressed syndecan-1 mRNA and protein at variable levels.
Gene_expression (expressed) of syndecan-1 mRNA associated with pancreatic cancer
1) Confidence 0.78 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.85 Pain Relevance 0.23
Decreased expression of syndecan-1 has been observed in some gastrointestinal malignancies, and it is thought that high levels of syndecan-1 correlate with the maintenance of epithelial morphology and inhibition of invasiveness.
Gene_expression (expression) of syndecan-1
2) Confidence 0.78 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.48 Pain Relevance 0.08
Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers.
Gene_expression (expression) of Syndecan-1 associated with gastrointestinal neoplasms
3) Confidence 0.78 Published 2000 Journal Int. J. Cancer Section Title Doc Link 10962434 Disease Relevance 0.64 Pain Relevance 0.14
Pancreatic cancer tissues markedly over-expressed syndecan-1 mRNA in comparison with both chronic pancreatitis (2.4-fold increase, p < 0.01) and normal pancreatic samples (10.6-fold increase, p < 0.01).
Gene_expression (expressed) of syndecan-1 mRNA associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.78 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.92 Pain Relevance 0.25
Large, frequently intrasinusoidal tumor cells expressed CD138, EMA, weakly IgA and kappa, but were negative for other B-cell markers, T-cell markers and CD30.
Gene_expression (expressed) of CD138 in T-cell associated with cancer
5) Confidence 0.75 Published 2005 Journal Pol J Pathol Section Abstract Doc Link 15921012 Disease Relevance 1.12 Pain Relevance 0.06
By in situ hybridization and immunohistochemistry, syndecan-1 expression was evident at relatively low levels in the ductal cells and less frequently in acinar cells of the normal pancreas.
Gene_expression (expression) of syndecan-1 in pancreas
6) Confidence 0.68 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 1.17 Pain Relevance 0.25
Together, our findings suggest that syndecan-1 expression by pancreatic cancer cells may be of importance in the pathobiology of this disorder and that its role in pancreatic cancer seems to be different from that in other gastrointestinal malignancies.
Gene_expression (expression) of syndecan-1 associated with pancreatic cancer
7) Confidence 0.60 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 1.08 Pain Relevance 0.14
In our study, we characterized the expression of syndecan-1 in normal, chronic pancreatitis and primary and metastatic human pancreatic cancer tissues, in cultured pancreatic cancer cell lines and in esophageal, gastric, colon, and liver cancers.
Gene_expression (expression) of syndecan-1 in liver associated with liver cancer, pancreatic cancer and chronic pancreatitis
8) Confidence 0.60 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.68 Pain Relevance 0.16
There was no difference in syndecan-1 mRNA expression between early and advanced tumors.
Gene_expression (expression) of syndecan-1 mRNA associated with cancer
9) Confidence 0.53 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 1.10 Pain Relevance 0.25
Natalizumab, a recently re-approved drug for MS treatment, has been shown to reduce the numbers of CD19+ B cells and CD138+ plasma cells within the CSF [32] which correlated with the reduction of relapse rates as well as of the inflammatory disease activity on MRI.
Gene_expression (plasma cells) of CD138 in plasma cells associated with multiple sclerosis, inflammation, disease, imagery and recurrence
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.95 Pain Relevance 0.50
At flow cytometry, these cells were positive for CD38, CD138, and negative for CD56 and CD20.
Neg (negative) Gene_expression (positive) of CD138
11) Confidence 0.41 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2944146 Disease Relevance 0.56 Pain Relevance 0.10
The majority of these B cells showed the expression pattern of mature B cells (phenotype: CD19+CD138?)
Gene_expression (expression) of CD138 in mature B cells
12) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 1.18 Pain Relevance 0.34
In our study, we characterized the expression of syndecan-1 in normal, chronic pancreatitis and primary and metastatic human pancreatic cancer tissues, in cultured pancreatic cancer cell lines and in esophageal, gastric, colon, and liver cancers.
Gene_expression (expression) of syndecan-1 in colon associated with liver cancer, pancreatic cancer and chronic pancreatitis
13) Confidence 0.21 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.68 Pain Relevance 0.16
For the detection of CD27, CD20, and CD138 expressing B cells, a live gate was set on the CD19+ cell population.
Gene_expression (detection) of CD138 in B cells
14) Confidence 0.20 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0 Pain Relevance 0
Peripheral blood CD19+ lymphocytes were gated and stained for expression of CD27 in combination with CD20 or CD138 expression.
Gene_expression (expression) of CD138 in lymphocytes
15) Confidence 0.18 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.58 Pain Relevance 0
Syndecan-1 was abundantly expressed in RA and PsA samples whereas it was absent in normal and weakly expressed in OA.
Neg (absent) Gene_expression (expressed) of Syndecan-1 associated with rheumatoid arthritis, osteoarthritis and arthritis
16) Confidence 0.17 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.59 Pain Relevance 0.18
Syndecan-1 and IgG immunoreactivity were negative in normal synovia.
Neg (negative) Gene_expression (negative) of Syndecan-1
17) Confidence 0.15 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.19 Pain Relevance 0.41
They are expressed in a cell-, tissue- and development-specific manner.1 Syndecan-1 and -4 have been shown in endothelial cells,3 however, syndecan-1 is mainly expressed on epithelial cells with syndecan-4 expression on many cell types.
Gene_expression (expressed) of syndecan-1 in epithelial cells
18) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.22 Pain Relevance 0
Syndecan-1 was present in the mononuclear infiltrates of synovia from patients with RA and PsA where it occurred in plasma cells.
Gene_expression (present) of Syndecan-1 in plasma cells associated with rheumatoid arthritis and arthritis
19) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.64 Pain Relevance 0.26
Therefore, this study aimed to compare the expression patterns of syndecan-1, -2, -3, and -4, and glypican-1, -3 and -4 in the RA, PsA and normal synovium.
Gene_expression (expression) of syndecan-1 in synovium associated with rheumatoid arthritis and arthritis
20) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.80 Pain Relevance 0.45

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